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Medicinal plants play important role in the development of therapeutic agents, for curing diseases. The study was conducted to evaluate the antibacterial activity of aqueous and ethanolic extracts of three medicinal plants; pomegranate (Punica granatum), black tea (Camellia) and Kharnoob (Prosopis farcta) against some antibiotic resistant isolates The agarwell diffusion method was used for the determination of the antibacterial activity of the extract at different concentration (25,50,100, and 200) mg/ml. The bacteria, isolated from infected wound and diarrheal stool, then identified using routine cultural, morphological, and biochemical testes, The Kirby-Bauer antibiotic susceptibility assay showed that the selected bacterial isolates demonstrated was high resistance to most common used antibiotics, and different multidrug resistance patterns had been seen. The results showed that aqueous and ethanolic extracts from the peels of P. granatum peels had strong activity against bacterial isolates from wound infections caused by Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Staphylococcus saprophyticus, and Escherichia coli. In addition, the aqueous and ethanolic extract of P. granatum pulp, and black tea leaves demonstrated high antibacterial activity against a number of bacterial isolates obtained from diarrheal stool