A variety of chromone-containing polycyclic compounds are efficiently constructed in good yields with excellent diastereoselectivities via palladium-catalyzed [2 + 2 + 1] annulation of 3-iodochromones, α-bromo carbonyl compounds, and tetracyclododecene.

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Optically pure 1,3-amino alcohol is not only the important synthon in organic synthesis, but also the core structure of numerous bioactive molecule. As a result, the formation of 1,3-amino alcohols occupies a hot resarch topic in asymmetric synthesis. This review symmarizes several types of frequently-used methods and progress on synthesizing 1,3-amino alcohols: aldol or azo-aldol condensation synthesis, transition metal catalyzed C-H activation and amination synthesis, ring-opening and addition of azocyclic compounds, and [3＋2] dipolar-cycloaddition reaction etc.