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Background College life represents a key transitional period in the life of young adults that is marked by increased social engagement; living habits acquired during this period have implications on the future life of college students. Therefore, investigation of the determinants of health status of college students is a key imperative; however, there is limited evidence on the study of concomitant effects of physical activity (PA), sedentary time (ST), and sleep duration on the health-related quality of life (HRQOL) of college students. Methods This cross-sectional survey was conducted at a medical university in Shenyang in Northeast China in 2017. The study group comprised 926 undergraduate students. Data were collected by a self-administered questionnaire. PA, ST, sleep duration, and HRQOL were measured using the international physical activity questionnaire (IPAQ)-Long Form and the Chinese version of the 12-Item Short-Form Health Survey (SF-12). The association of PA, ST, and sleep duration with the HRQOL was examined using independent t -test, Pearson Chi-squared test, and multivariate linear regression analysis. Results After adjusting for potential confounding factors, students who reported high PA had significantly higher physical component summary (PCS) score in the total study population and among female students than those who reported low PA, whereas students who reported moderate PA had significantly higher PCS score only among female students ( P < 0.05). In the total study population and among male students, students who slept for ≥9 h/day had significantly higher mental component summary (MCS) score than those who slept for 7–< 8 h/day, whereas among only male students, those who slept for 8–< 9 h/day had significantly higher MCS score ( P < 0.05). The interaction term between ST and PA was not statistically significant. Conclusions PA and sufficient sleep duration had a positive impact on the HRQOL of college students; however, ST was not associated with HRQOL and there was no interaction between the impact of ST and PA on the HRQOL of college students. Increasing PA and promoting adequate sleep duration are key health promotion strategies for college students.

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Objective To evaluate the correlation of the maximum six minutes of daily activity (M6min) with standard measures of functional capacity among older adults with heart failure (HF) in comparison to younger subjects and its prognostic utility. Design Prospective, cohort study. Setting Tertiary care, academic HF center. Participants Sixty, ambulatory, adults, NYHA Class I-III, stratified into young (51±10 years) and older cohorts (77±8 years). Intervention Continuous actigraphy monitoring on the non-dominant wrist. Measurements Correlation between M6Min and measures of functional capacity (6 minute walk distance; 6MWT) and with peak VO2 by cardiopulmonary exercise testing in a subset. Survival analysis was employed to evaluate the association of M6Min with adverse events. Results Compliance with actigraphy was high (90%) and did not differ by age. The correlation between M6min and 6MWT was higher in subjects ≥ 65 years of age than those <65 years of age (r=0.702, p=0.0002 vs. r=0.490, p=0.002). M6min was also significantly associated with peak VO2 (r=0.612, p=0.006). During the study, 26 events occurred (2 deaths, 10 hospitalizations, 8 emergency room visits and 6 intercurrent illnesses). The M6min was significantly associated with subsequent events (Hazard ratio of 2.728; 95% CI: 1.099–6.775, p=0.031) independent of age, gender, ejection fraction, NYHA class, brain natriuretic peptide, and 6MWT. Conclusions The high compliance with actigraphy and association with standard measures of functional capacity and independent association with subsequent morbid events suggests that it may be a useful for monitoring older adults with heart failure.