Ovarian serous cystadenocarcinoma is a common malignant tumor of female genital organs. Treatment is generally less effective as patients are usually diagnosed in the late stage. Therefore, a well-designed prognostic marker provides valuable data for optimizing therapy. In this study, we analyzed 303 samples of ovarian serous cystadenocarcinoma and the corresponding RNA-seq data. We observed the correlation between gene expression and patients' survival and eventually established a risk assessment model of five factors using Cox proportional hazards regression analysis. We found that the survival time in high-risk patients was significantly shorter than in low-risk patients in both training and testing sets after Kaplan-Meier analysis. The AUROC value was 0.67 when predicting the survival time in testing set, which indicates a relatively high specificity and sensitivity. The results suggest diagnostic and therapeutic applications of our five-gene model for ovarian serous cystadenocarcinoma.

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We present a self-supervised approach to estimate flow in camera image and top-view grid map sequences using fully convolutional neural networks in the domain of automated driving. We extend existing approaches for self-supervised optical flow estimation by adding a regularizer expressing motion consistency assuming a static environment. However, as this assumption is violated for other moving traffic participants we also estimate a mask to scale this regularization. Adding a regularization towards motion consistency improves convergence and flow estimation accuracy. Furthermore, we scale the errors due to spatial flow inconsistency by a mask that we derive from the motion mask. This improves accuracy in regions where the flow drastically changes due to a better separation between static and dynamic environment. We apply our approach to optical flow estimation from camera image sequences, validate on odometry estimation and suggest a method to iteratively increase optical flow estimation accuracy using the generated motion masks. Finally, we provide quantitative and qualitative results based on the KITTI odometry and tracking benchmark for scene flow estimation based on grid map sequences. We show that we can improve accuracy and convergence when applying motion and spatial consistency regularization.

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