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The data is presented characterizing specifics of level, dynamics and structure of mortality of blood circulation system diseases among total population and individuals of able-bodied age in the regions of the Republic of Bashkortostan according data from the Territorial agency of the Federal service of state statistics in 2002-2015. The decreasing is established of both total intensive and standardized indices of mortality of blood circulation system diseases that corresponds all-Russian trends. However, decreasing of average age of the deceased occurred. The negative dynamics of mortality of blood circulation system diseases is established. The statistically significant differences in the levels of mortality of ischemic heart disease between considered regions of the Republic of Bashkortostan and average Russian indices are revealed. In spite of being outlined decreasing tendency the level of mortality of blood circulation system diseases continues to be quite high and requires further investigation of all its aspects.

The study involved 52 women with rheumatoid arthritis, aged 18 to 29, including 19 pregnant women. The comparison of the clinical features of the process activity with the content of cortisol in the blood, anti-lymphocytic antibodies and rheumatoid factor was carried out. In women with rheumatoid arthritis, a decrease in the content of cortisol with a tendency to an increase in the titer of anti-lymphocyte antibodies and a significant increase in these indicators during pregnancy was found. Low cortisol levels were observed in the exacerbation phase of the rheumatoid process. The data obtained indicate the effect of the concentration of cortisol in the blood and the titer of anti-lymphocyte antibodies on the pathogenesis of rheumatoid arthritis, as well as the need to develop a tactic for treating women with this pathology.

A clinical assessment of the presence of osteoarthritis (OA) with various localizations, undifferentiated connective tissue dysplasia (uCTD) and joint hypermobility (JHM) in 484 individuals of both sexes of different age groups was carried out. We searched for associations of 4 polymorphic variants of matrix metalloproteinase genes (rs35068180 (MMP3), rs2252070 (MMP13) ), rs226794 and rs2830585 (ADAMTS5)) with the development of osteoarthrosis as a whole, taking into account the localization of the pathological process, the age of the patients, the ethnic origin of the study groups and the presence of undifferentiated connective tissue dysplasia as a whole and its individual phenotypic markers, as well as in the comorbid state with osteoarthritis was carried out. 158 patients had osteoarthritis, 252 had a symptom complex of uCTD, 92 of them were in the comorbid state with OA. The significance of the polymorphic loci of MMP3, MMP13, ADAMTS5 genes in the formation of the symptom complex of uCTD in general and its individual phenotypes was detected. The polymorphic locus of MMP3 gene was associated with OA in the comorbid state with uCTD. Statistically significant models based on clinical-genetic data using the method of multiple logistic regression, that allow predicting the development of osteoarthrosis of knee, hip joints and polyosteoarthrosis were calculated.