Uremic pruritus is a common and intractable symptom in patients on chronic hemodialysis. It causes serious discomfort and skin damage, negatively affects the quality of life, and may be associated with sleep disturbance, inflammation, and higher mortality . The aim of the present study was to assess serum level of osteopontin [OPN] in patients with uremic pruritus undergoing hemodialysis and evaluation of its clinical significance and its role in the pathogenesis of Uremic Pruritis. This is a case control study that was conducted on 80 patients with end stage renal disease undergoing hemodialysis; 40 of them were suffering from uremic pruritus [Group A] and 40 patients were not suffering from it [Group B]. All patients were recruited from the hemodialysis unit of Benha University Hospital between May 2017 and July 2018, All studied subjects were tested for serum level of Osteopontin[Opn] in both patients groups using an ELISA technique, the results of the study revealed that OPN showed 95 % sensitivity and 90 % specificity in predicting pruritus in CKD patients undergoing hemodialysis when the cut off value 50 pg/ml. Osteopontin [OPN] may play a role in the pathogenesis of uremic pruritus and can be used as a sensitive biomarker in predicting UP in chronic kidney disease patients undergoing hemodialysis.

Acne, also known as acne vulgaris (AV), is a long-term skin disease that occurs when hair follicles are clogged with dead skin cells and oil from the skin. The investigation is expected to evaluate serum level of betartophien protein in patients with skin break out vulgaris and contrast it with its level in solid control. This is A case -control study, was led on 80 patients isolated into 2 groups:(Group A); 60 patients experiencing skin break out vulgaris, (Group B); 20 obviously sound people of coordinated age and sex. All examined subjects were tried forSerum level of Betatrophin. Higher betatrophien level was altogether connected with higher seriousness higher betatrophien level was fundamentally connected with male sexual orientation, PCOD, hairsuitism, androgenetic alopecia. The betatrophien level in AV bunch was essentially higher when contrasted with control gathering . Betatrophien level was proposed to be autonomous indicator of AV defenselessness and seriousness.

Uremic pruritus is a common and intractable symptom in patients on chronic hemodialysis. It causes serious discomfort and skin damage, negatively affects the quality of life, and may be associated with sleep disturbance, inflammation, and higher mortality.The aim of the present study was to assess serum level of Fibroblast growth factor 23 [FGF 23] in patients with uremic pruritus undergoing hemodialysis to evaluate its role in uremic pruritus pathogenesis and evaluation of its clinical significance.The present study was conducted as a comparative cross-sectional study, study included 80 patients with end stage renal disease undergoing hemodialysis; 40 of them were suffering from uremic pruritus [Group A] and 40 patients were not suffering from it [GroupB]. All patients were recruited from the hemodialysis unit of Benha University Hospital between May 2017 and July 2018, All studied subjects were tested for serum level of endothelin-1 [ET-1] 1 in both patients groups using an ELISA technique.There was no significant difference of the serum level of FGF 23 regarding age, biochemical parameters and VAS score of pruritus. While, the duration of hemodialysis was significantly longer among group A patients [p 0.001].Fibroblast growth factor 23 may play a role in the pathogenesis of uremic pruritus and can be used as a sensitive biomarker in predicting uremic pruritus in chronic kidney disease patients undergoing hemodialysis.