The pathophysiological changes underlying impairment of cognition in Parkinson's disease (PD) are complex and not fully understood till date. Hence, understanding the structural changes responsible for cognitive decline in PD is essential for early diagnosis and to offer effective treatment. In this review, we discuss the neuroanatomical changes in major brain structures responsible for cognition in PD. We have included the key findings of various studies to provide up-to-date information for better understanding of pathophysiology of PD, which will help researchers and clinicians in planning and developing new treatment methods for the benefit of PD patients.
It was observed that the bony bars between the three clinoid processes can be divided into four types (Types I, II, III, IV). Due to the presence of these bars three types of interclinoid foramina were formed. A total incidence of 22% of various types of interclinoid bars was observed, out of which 12% were Type I, 5.6% Type II, 4% type III and only 0.4% were of type IV variety.
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