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Continuous-motion imaging provides a method for the rapid quantitative analysis of slide-mounted cell preparations. Densitometric and morphometric cellular features can be measured and used to classify individual cells. Tests on the densitometric accuracy of the CERVIFIP CMI system show a c.v. of 6.5% for diploid mouse hepatocytes and a measuring rate of up to 500 cells/sec. CMI is particularly useful for problems requiring the interactive analysis of rare cell types and for the measurement of morphological and densitometric characteristics of cell populations. Typical applications include the prescreening of cervical cytology specimens and the detection of rare autoradiographically labeled lymphocytes.

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METAFIP is an image analysis system designed to find cells in metaphase state on a microscope slide for subsequent recall, and eventually to rank them in accordance with some quality criteria. It is based on the Fast Interval Processor (FIP), a high speed image analyser, which scans the image using a linear charge coupled diode array.Slide scan rates of 4sq mm. /sec. have been achieved without saturating the computer. An 8MHz stream of pixel density values is reduced to a data rate which can be digested in a fast minicomputer using interval coding. The paper describes how the interval parameters (or features) extracted by the hard -wired pre -processer are used by the metaphase finding algorithms. Results are given showing encouraging discrimination between metaphase and non -metaphase cells on a variety of materials.

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