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Calophyllolide, a nonsteroidal anti-inflammatory agent, was found to be effective in reducing the increased capillary permeability induced in mice by various chemical mediators involved in the inflammatory process viz, histamine (HA), 5-hydroxytryptamine (5-HT) and bradykinin (BK). Pretreatment with calophyllolide (p. o.) afforded significant protection against induced increase in capillary permeability by HA (PD50 144.1 mg/kg), 5-HT (PD50 250.0 mg/kg) and BK (PD50 133.5 mg/kg). Clinical studies with calophyllolide in different inflammatory disorders are warranted, in view of its very similar safety margin to oxyphenbutazone (21.4 mg/kg and 25 mg/ kg respectively).

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