Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability

Saxena, R. C.; Nath, Rajendra; Palit, G.; Nigam, S. K.; Bhargava, K. P.

doi:10.1055/s-2007-971459

Cited by 19 publications

(12 citation statements)

References 5 publications

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“…Calophyllolide (Figure 1) is the representative coumarin in C. inophyllum . Calophyllolide has been reported to exhibit some biological activity, including anti-inflammation, lower capillary vascular permeability [14], anti-cancer [15], anti-microbial [10], and anti-coagulant [9] properties.…”

Section: Introductionmentioning

confidence: 99%

Calophyllolide Content in Calophyllum inophyllum at Different Stages of Maturity and Its Osteogenic Activity

Liu¹,

Liu

Chen

et al. 2015

Molecules

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Calophyllum inophyllum is a coastal plant rich in natural substances. Its ingredients have been used for the development of an anti-human immunodeficiency virus (HIV) drug. In this study, we collected C. inophyllum fruit, and the ethanol extract of the fruit was chromatographically separated using silica gel and Sephadex LH-20 columns to obtain the major compound, calophyllolide. The fruits were harvested from September to December in 2011; a quantitative analysis of the calophyllolide content was conducted using HPLC to explore the differences between the different parts of the fruit during the growing season. The results showed that in fruits of C. inophyllum, calophyllolide exists only in the nuts, and dried nuts contain approximately 2 mg·g −1 of calophyllolide. The calophyllolide levels in the nuts decreased during maturity. In addition, calophyllolide dose-dependently OPEN ACCESSMolecules 2015, 20 12315 enhanced alkaline phosphatase (ALP) activity in murine osteoblastic MC3T3-E1 cells, without significant cytotoxicity. The expression of osteoblastic genes, ALP and osteocalcin (OCN), were increased by calophyllolide. Calophyllolide induced osteoblasts differentiation also evidenced by increasing mineralization and ALP staining.

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Section: Introductionmentioning

confidence: 99%

Calophyllolide Content in Calophyllum inophyllum at Different Stages of Maturity and Its Osteogenic Activity

Liu¹,

Liu

Chen

et al. 2015

Molecules

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“…A. moluccana oil is also used to treat conditions such as ulcers, rabies and asthma, and it has anti-bacterial activity [11, 12]. Calophyllum inophyllum oil also has demonstrated therapeutic effects, which include healing and anti-inflammatory actions [13, 14]. This oil is already used in skin-healing creams at a concentration of 30%.…”

Section: Introductionmentioning

confidence: 99%

Ocular Burn: Rinsing and Healing with Ionic Marine Solutions and Vegetable Oils

et al. 2008

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Purpose: We investigated the effects of various rinsing and healing protocols on corneal wound repair and inflammation following alkali burn in rabbits. Methods: We conducted in vitro, in vivo and ex vivo studies. First, different rinse solutions were tested in vitro after incubation of ocular cells with methanol or NaOH. Cell viability was then assessed using the neutral red test (cytofluorometry). Second, NaOH was applied to rabbit corneas and associations of rinse solutions (NaCl 0.9% or controlled ionization marine solutions) with N-acetylcysteine or vegetable oils (from Calophyllum inophyllum and Aleurites moluccana) were tested in vivo. The regeneration of the corneal epithelium and the infiltration of inflammatory cells were evaluated using in vivo confocal microscopy and ex vivo histological cuts. Results: The association of a controlled ionization marine solution with 10% C. inophyllum oil and 90% A. moluccana oil induced regeneration of the corneal epithelium and a decrease in inflammatory cells. Conclusions: Irrigation with marine solution followed by treatment with a mixture of C. inophyllum and A. moluccana oils is a promising treatment for ocular burns.

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“…Tamanu oil demonstrates anti-inflammatory activity. This activity is due partly to the 4-phenyl coumarin calophylloide [8][9] and to a group of xanthones in the oil, including dehydrocycloguanandin, calophyllin-B, and euxanthone. Al the xanthones in tamanu oil show anti-inflammatory activity 10 .…”

Section: Kashman and Patil Reported That (+) -Calanolide A And Inophymentioning

confidence: 99%

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2016

IJPSR

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Cancer is a major health problem; almost thought -out the world. Herbal medicines have a vital role in the prevention and treatment of cancer. The present study, the in vitro anticancer activity of Calophyllum inophyllum ethanolic leaf extract was evaluated in MCF-7 Breast cancer cell lines. Anticancer activity was evaluated with MTT standard colorimetric assay against MCF-7 cells with IC50 value of 120µg/mL. The biologically active metabolites were identified and quantified by a GC-MS method shows presence of 11 different bioactive compounds. The cytotoxic effect was found to be concentration dependent. Increased concentration of the leaf extract showed increased cytotoxicity.

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Effect of Calophyllolide, a Nonsteroidal Anti-Inflammatory Agent, on Capillary Permeability

Cited by 19 publications

References 5 publications

Calophyllolide Content in Calophyllum inophyllum at Different Stages of Maturity and Its Osteogenic Activity

Calophyllolide Content in Calophyllum inophyllum at Different Stages of Maturity and Its Osteogenic Activity

Ocular Burn: Rinsing and Healing with Ionic Marine Solutions and Vegetable Oils

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