1 The plasma pharmacokinetics of metronidazole following a single dose (500 mg) of metronidazole have been investigated in a crossover study in healthy female volunteers, using assays specific for metronidazole and its metabolites 1-(2-hydroxyethyl)-2-hydroxymethyl-5-nitroimidazole (metabolite I) and 2-methyl-5-nitroimidazole-l-acetic acid (metabolite II). 2 No systematic differences, which could be related to the route of metronidazole administration, were observed in the area under the plasma metronidazole concentration against time curve, elimination half-life, apparent volume of distribution, or total urinary excretion of metronidazole. Following a single oral or intravenous dose, the half-life estimates were 7.0 h and 7.3 h respectively. 3 No metabolite II was detected in plasma following the administration of metronidazole by either route. Urinary elimination of this metabolite appeared to be independent of the route of administration. 4 No systematic differences, which could be related to the route of administration, were observed in the apparent half-life or total urinary excretion of metabolite I. However, the area under the plasma concentration against time curve for metabolite I was significantly greater (+27%) following oral administration than following intravenous administration. 5 A single dose of metronidazole (500 mg) produced a peak plasma concentration for the drug which was in excess of the minimum inhibitory concentration of most susceptible anaerobic bacteria, and in several of the volunteers such an inhibitory concentration ofmetronidazole was maintained in plasma for more than 8 h following a single dose.

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One of the major questions that has arisen in the field of neuropsychology deals with the effectiveness of the Luria-Nebraska Neuropsychological Battery as compared with the Halstead-Reitan Neuropsychological Battery, which has been recognized by many as the preeminent standardized battery. The present study compared the major 14 scores of the Halstead-Reitan battery with the 14 summary scale scores of the Luria-Nebraska battery to investigate whether the batteries could predict one another and their effectiveness in a common sample of 48 brain-damaged and 60 normal patients. Discriminant analysis found both batteries equally effective in identifying brain damage, with hit rates over 85%. A high degree of relationship (all Rs > .71, p < .05) between the Luria-Nebraska scale scores and the selected 14 scores of the Halstead-Reitan was found.

NCT01356719.

No abstract