Transfer of free fatty acids across the primate placenta. Am. J. Physiol. 216(l) : 143-147. I969.-The transfer of linoleicand palmitic-lJ4C acids from mother to fetus and vice versa was studied in monkeys prepared with maternal and fetal arterial and venous catheters. Both fatty acids were rapidly transferred across the placenta. The mechanisms of transfer of fatty acids were investigated by measuring sequences of esterifications in plasma and other

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Liver blood flow in infant monkeys (M speciosa) was measured with both the fractional clearance flow rate technique and the microsphere technique in an attempt to evaluate these methods comparatively and to quantitate liver blood flow in the newborn nonhuman primate. Cardiac output, blood volume and regional hepatic arterial, splenic, gastrointestinal, pancreatic and mesenteric blood flows were determined. With the fractional clearance technique mean liver sinusoidal blood flow was 35.2 ml/min or 1.48 ml/min/g of liver; this represents 26.3% cardiac output. With the microsphere method mean liver blood flow was 23.8 ml/min or 1.02 ml/min/g of liver; this represents 18.0% cardiac output. In these infants the mean cardiac output was 190 ml/min/kg body weight and the mean blood volume was 92.4 ml/kg.

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The 02 pressure, saturation and capacity, the pH and CO2 pressure in the arterial blood of nonanawsthetized sheep were measured at two altitudes (1600 and 4340 metres). At high altitude sheep carriers of A heemoglobin had a mean arterial saturation significantly higher than the B haemoglobin carriers (864 ±0-6 vs. 67-5±1-0). The carriers of a mixture of A and B haemoglobins hadanintermediate saturation: 77-0±1-0. There was no significant difference among the three groups in arterial Po2, pH, PC02, oxygen capacity and haematocrit.Two haemoglobin types, A and B, are commonly present in the blood of healthy, adult sheep. These types are inherited as mendelian traits [Evans et al., 1956]. Both hsemoglobins are present in about equal amounts in the blood of the heterozygote. In anaemic animals with A haemoglobin a third type, haemoglobin C, appears in large quantities in the blood [Van Vliet et al., 1964].At the same temperature and plasma pH, the blood with B haemoglobin has a lower oxygen affinity than the blood with A hsemoglobin; the 02 affinity in the heterozygous sheep is intermediate [Naughton et al., 1963].The presence of animals with widely different whole blood oxygen dissociation curves within the same species provides a valuable tool in the investigation of blood oxygen transport and tissue respiration. Dawson and Evans [1965] have described significant differences in haematocrit, arterial oxygen saturation and blood volume between A and B haemoglobin carriers at low altitude. The same authors [Dawson and Evans, 1966] exposed anaesthetized sheep to a very low oxygen pressure in the inspired air (63 mm Hg) for 20 minutes and showed that A hsemoglobin carriers were more resistant to this type of hypoxia.In the experiments described in this paper we have studied some of the respiratory gas changes that take place in the arterial blood of A, B and AB carriers upon exposure to high altitude.