Station expérimentale d'Avicullure B.P. 9 , 22ggO Ploulragaîz (France) Rabhits held 1 days in an ammonia environment at the level of 30 ppm (S + ) and rabbits in a normal environment (S-) were intranasally inoculated 4 times with Pasteurella multocida (io l bacteria j inoculuiu).In the sensibilized animals (S + ) lung lesions were significantly more frequent and more acute than in the non sensibilized ones (S-). Bacteriological investigations showed that in the (S-) rabbits, the mucosa of the upper respiratory tract had entirely played its role in filtrating and destructing the bacteria : in (S-) animals, lungs were sterile or poorly infected whereas in (S + ) animals, they were heavily contaminated.Use of the dermojet apparatus for vaccinations against myxomatosis M. DURAND R. LOQUERIE Laboratoire Roger l3ellon, Département t!/!!/7?f!f!, i5g, avenue du Roule, 92200 1'"e H illy>-. Çl (J'-.5e.iHé' (France)The DERMOJET is an injector apparatus without needle used to vaccinate rabbits by simple projection of the vaccine at the inner side and towards the basis of the external ear. However, this apparatus must be used with precautions and the instructions must be followed carefully when vaccinating against myxomatosis.The procedure is only fully efficient in very young, newly weaned rabbits, but the protection obtained, although rapid is transitory. It

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RÉSUMÉPrenant appui sur le succès d'une campagne de vaccinations dans une porcherie victime de maladie d'Aujeszky, un programme de prophylaxie médicale, à l'aide d'un vaccin inactivé à adjuvant huileux, a été institué dans un élevage bovin cliniquement atteint de rhinotrachéite bovine infectieuse (R.B.I.). Un contrôle continu des risques endogènes de réinfec tion, à travers la sérologie de veaux «sentinelles» nés de mères immunes, mais non vaccinés eux-mêmes, permet de conclure à la disparition plausible de l'agent infectieux au terme de quatre années de vaccinations ininter rompues. La méthode ELISA et la séroneutralisation classique s'accordent à reconnaître que la disparition des anticorps d'origine colostrale est progres sive et régulière jusqu'à un âge maximum de 180 jours où la négativation sérologique paraît définitive. Facilité par le renouvellement des générations, un moyen pratique de dépistage permet donc de vérifier le pouvoir immunogène de certains vaccins contre les malades animales à herpès virus. BULLETIN DE L'ACADÉMIE SuMMARYBased on the success of a campaign of vaccinations in a pig farm affected by Aujeszky's Disease, a program of medical prophylaxis using an inactivated vaccine with oily adjuvant, was set up in a cattle breeding farm which was clinically affected by Infectious Bovine Rhinotracheitis (l.B.R.). A continous control of the endogenous risks of reinfection through the serology of « sentry » calves, born to immune mothers, but not vaccinated themselves, makes it possible to conclude in favor of the plausible disappearance of the infectious agent at the end of four years of uninterrupted vaccinations : the ELISA method and the classic seroneu tralization both concur in the recognition that the disappearance of the antibodies of colostrum origin is progressive and regular up until a maximum age of 180 days when the serologic negativation seems perma nent. Made easier by the renewal of generations, a practical means of detection enables the verification of the immunogenic power of certain vaccines against animais diseases due to herpes-virus.

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