N. sativa administration in patients with HCV was tolerable, safe, decreased viral load, and improved oxidative stress, clinical condition and glycemic control in diabetic patients.

While researchers are struggling to develop a vaccine for coronavirus disease, it is important to evolve effective therapeutic strategies to save lives. The majority of coronavirus disease deaths are due to pneumonia. Mostly, stress and depression are associated with coronavirus disease infection and thus, resulting in weakening of patients’ immune response and hence, more severe respiratory symptoms or even death. We propose using a class of antidepressants named selective serotonin reuptake inhibitors for their reported potential antiviral effect, modulatory effect of respiratory symptoms, antioxidant properties and immunoregulatory effects beside their main action as antidepressant. In addition, the low cost of selective serotonin reuptake inhibitors might add a benefit for coronavirus disease patients.

No abstract

Background The devastating adverse effects of interferon (IFN) for the treatment of hepatitis C virus (HCV) lead to the emerging of direct acting antiviral agents (DAAs). This investigation was undertaken to assess safety and efficacy of two Egyptian DAA protocols for HCV: sofosbuvir (SOF)/daclatasvir (DCV)/simeprevir (SMV)/ribavirin (RBV) and sofosbuvir (SOF)/ombitasvir (OMB)/paritaprevir (PTV)/ritonavir (RTV)/RBV for 12 weeks in treatment-experienced HCV Egyptian patients. Methods It is a retrospective study where 139 patients, out of 400 patients, were divided according to their documented treatment protocol into two groups (Gp1: SOF/DCV/SMV/RBV and Gp2: SOF/PTV/OMB/RTV/RBV). All patients’ physical examination, disease history, laboratory baseline, and end of treatment data were collected from their profiles, evaluated and compared. Results Gp1 and Gp2 regimens had achieved sustained virologic response rates (SVR12) of 96.6% and 95.1%, respectively. Hemoglobin, ALT, and AST had decreased significantly (P < 0.05) in the two groups. Total bilirubin level had increased significantly in Gp1 and Gp2 (P = 0.002 and < 0.001, respectively). Creatinine level had increased significantly (P = 0.002) in Gp1 at end of treatment, while Gp2 remained unchanged. Headache and fatigue were the most common side effects in both protocols. Conclusions SOF/DCV/SMV/RBV and SOF/PTV/OMB/RTV/RBV regimens achieved high similar efficacy in Egyptian treatment-experienced HCV patients. Even though the outcome was with tolerable side effects, a better treatment regimen was recommended to abate these side effects for the welfare of Egyptian HCV patients.

Background: Mental health issues have been increasing globally, especially among university students. The pandemic of COVID-19 has aggravated this pre-existing and serious problem. This study aimed to assess the stress and depression levels and mental health status of Egyptian university students during the COVID-19 pandemic.Methods: A cross-sectional online survey was conducted on medical and non-medical Egyptian university students. A total of 1470 participants completed the electronic anonymous online survey containing Patient Health Questionnaire-9 (PHQ-9) and Perceived Stress Scale(PSS). Results: Of the 1470 participants, 10.9% have moderately severe depression and 6.1% have severe depression. Moreover, 77.6% reported moderate stress, 16.3% reported low stress, and 6.2% reported high stress. There was strong positive correlation between depression and stress among participants (r = 0.815) (p < 0.001). The significant predictors for depression were age between 18 and 20 years, female sex, presence of chronic diseases, and presence of friends or relatives diagnosed with COVID-19. The significant predictors for stress were age between 18 and 20 years, female sex, presence of friends or relatives diagnosed with COVID-19, and medical faculties.Conclusions: During the COVID-19 pandemic, a majority of university students of Egypt showed moderate to high level of stress, and about one-third of them had moderate to severe depression. Younger age, female sex and having a relative or friend diagnosed with COVID-19 were significant predictors for high stress level and depression. Psychological interventions for university students during the COVID-19 pandemic are strongly recommended to promote their mental health and improve academic achievement.