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INTRODUCTION: The teaching-learning based optimization (TLBO) algorithm is a recently developed algorithm. The proposed work presents a design of a master-slave TLBO algorithm. OBJECTIVES: This research aims to design a master-slave TLBO algorithm to improve its performance and system utilization for CEC2006 single-objective benchmark functions. METHODS: The proposed approach implemented using OpenMP and CUDA C, a hybrid programming approach to enhance the utilization of the system's computational resources. The device utilization and performance of the proposed approach evaluated using CEC2006 benchmark functions. RESULTS: The proposed approach obtains best results in significantly reduced time for CEC2006 benchmark functions. The maximum speed-up achieved is 30.14X. The average GPGPU utilization is 90% and the average utilization of logical processors is more than 90%. CONCLUSION: The master-slave TLBO algorithm improves the utilization of computational resources significantly and obtains the best results for CEC2006 benchmark functions.