Introduction: Seizures are more common in the neonatal period than in any other stage and affects approximately 1% of all neonates. Amongst neurological disorders, seizures are the most common in neonates. The study was conducted to determine the aetiology and clinical profile of neonatal seizures. Materials and Methodology: This study was designed to be a hospital based prospective observational study was undertaken in the in the hospital attached neonatal intensive care unit (NICU), RIMS, Raichur. A total of 500 neonates presenting with seizures or who developed seizures in hospital from 01 February 2022 to 31 May 2022 were enrolled in the study. All neonates (age 0 – 28 days) who presented to the hospital with history of seizures or who develop seizures during the course of hospital stay were taken into study. Detailed antenatal history examination and clinical details of each seizure episode reported by the mother and subsequently observed by the resident doctors on duty were recorded. Results: Among these 405 patients (81%) were from rural areas and 95 patients (19%) were from urban areas.