BACKGROUND: Condyloma acuminata (CA), also known as anogenital warts, is a predominantly sexually transmitted disease caused by the Human Papillomavirus (HPV). The most common strains of HPV that causes anogenital warts are Type 6 and 11. This vdisease affects the mucous membrane as well as skin of the external genitalia and perianal areas. There are several therapeutic modalities for CA such as destructive and surgical therapies; however, these therapies can pose side-effects mostly tissue destruction. Alternative modalities such as using betel leaf can be atreatment option for CA. CASE REPORT: In this paper, we report a 31-year-old female with CA who experienced clinical improvement after 3 weeks of office-made 60% topical betel leaf extract therapy, prompting more thorough research on the possible use of herbal treatments for treating CA. CONCLUSION: Office-made betel leaf extract therapy is a promising topical therapy for CA and is relatively simple to prepare. The plant has various mechanisms such as anti-proliferative and cytotoxic properties that can be studied further to prove its efficacy in the treatment of CA to prevent adverse events caused by other conventional destructive treatment modalities.