No abstract

From our research we noticed that Acanthi balcanici herba (ABH) contains luteolin and quercetol and Myrtillus fructus (M-fr) contains chlorogenic acid, apigenol and rutoside. ABH has no antibacterial effect on any species tested, completely cancel the therapeutic effect of three drugs (amoxicillin + clavulanic acid, levofloxacin, amikacin) and have no significant effect on the other two antibiotics (cefotaxime and ceftazidime) when they are associated. All bacterial species were sensitive to M-fr and the extract has synergistic effect in combination with levoflaxacin, amikacin and cefotaxime.

Polyphenols are important constituents of plants, being demonstrated that long term consumption of them have potential health benefits as antioxidant. In the experimental part of the study we separated ten polyphenolic compounds by thin layer chromatography (TLC) from hydroalcoholic hypoglycemic plant extracts (Ericaceae family). In the theoretical study part we consider important to characterize the structural properties of the substances using molecular mechanics studies. The selected physico-chemical descriptors were: HOMO and LUMO orbitals frontier, water solubility, partition coefficient, dipole moment, heat of formation, stabilization energy of the molecule and number of proton donor groups. We realized a comparative QSPR regression correlation study of molecular surface area and Rf with the selected desriptors. From studies we observed the relationship between the two parameters Rf and MSA, which correlates very well with common descriptors.

Statins are a class of lipid-lowering medications that reduce cardiovascular disease and mortality in pacients who are at high risk. The molecular docking technique has become an increasingly important tool for drug discovery which help us understand the most stable conformations resulting from ligand-active site of the biological receptor interaction. Partial atomic charges was determined for each molecule showing that the interaction of statins with the receptor is through areas of increased electronic density. The present molecular docking study using Autodock 4.2 was conducted in order to achieve accurate predictions of the best way for bonding and minimum bonding energy, method being applied for five statins drugs as potential inhibitors of HMG-CoA reductase enzyme. The results highlight that simvastatin represent the best inhibitory drug of HMG-CoA reductase enzyme, because the complex simvastatin-enzyme has the lowest binding energy value.

The study objectives were to determine the chemical composition and the synergistic / antagonistic effect of the association between hydroalcoholic extract from the Dorycnii pentaphylli herba (DPH) and the antibiotics of choice, on five reference strains. The tincture contains flavonoids and polyphenol carboxylic acids in low concentrations. DPH has an antagonistic effect on three of the drugs tested (amoxicillin + clavulanic acid, levofloxacin, amikacin), the therapeutic effect being completely canceled and has no significant effect on two of them (ceftazidime, cefotaxime).