ABSTRACT. The aim of this study was to compare genomic selection methodologies using a linear mixed model and the Cox survival model. We used data from an F2 population of pigs, in which the response variable was the time in days from birth to the culling of the animal and the covariates were 238 markers [237 single nucleotide polymorphism (SNP) plus the halothane gene]. The data were corrected for fixed effects, and the accuracy of the method was determined based on the correlation of the ranks of predicted genomic breeding values (GBVs) in both models with the corrected phenotypic values. The analysis was repeated with a subset of SNP markers with largest absolute effects. The results were in agreement with the GBV prediction and the estimation of marker effects for both models for uncensored data and for normality. However, when considering censored data, the Cox model with a normal random effect (S1) was more appropriate. Since there was no agreement between the linear mixed model and the imputed data (2015) (L2) for the prediction of genomic values and the estimation of marker effects, the model S1 was considered superior as it took into account the latent variable and the censored data. Marker selection increased correlations between the ranks of predicted GBVs by the linear and Cox frailty models and the corrected phenotypic values, and 120 markers were required to increase the predictive ability for the characteristic analyzed.

No abstract

According to World Health Organization, influenza and acute respiratory infections (ARI) affect more than 30% of the population each year. In Ukraine the burden of costs for medicines are mainly paid by patients out of pocket. MethOds: We analyzed the statistics of the Ministry of Health of Ukraine, the incidence of influenza and ARI, the Protocol for diagnosis and treatment of novel influenza A (H1 / N1) (CA) in adults in Ukraine and used the pharmacoeconomic method «Cost of illness».

The metanalysis studies demonstrated that the surgical staplers contributed with insignificant reduction of surgical time (5.18 and 1.56 minutes). Considering institutional costs at our Hospital, from January to September, 2014, surgical staplers and charge spent R$331,477.29 (€ 9544.83), 25% higher than the value reimbursed by the Brazilian health public system (SUS). ConClusions: Considering the literature evidence and costs analysis for our scenario the Hospital restricted the surgical stapler use exclusively for surgeries in which it is reimbursed by the public system of Brazilian health.

A927outra forma. Conforme a Dynamed, a metilprednisolona IV como terapia adjuvante, reduz a probabilidade de deterioração da oxigenação, insuficiência respiratória e/ou a morte por Pneumocystis jiroveci (anteriormente chamada de P. carinii) moderada a grave em HIV positivos. A terapia preferida tem sido a prednisolona via oral ou metilprednisolona via IV. A base UpToDate, demonstra, semelhante a base BMJ, o tratamento de primeira escolha para pacientes que apresentam tolerância deve ser sulfametoxazol associado à trimetoprima. Embora os estudos não tenham demonstrado a dose ou duração do tratamento ideal com corticosteróides, o uso por 21 dias via oral é recomendado. Metilprednisolona IV pode ser substituída por prednisolona oral a 75% se a terapia IV for necessária. ConClusions: A metilprednisolona pode ser utilizada no tratamento de PPC, pois reduz a incidência de mortalidade e insuficiência respiratória grave associada com PPC. Entretanto, recomenda-se metilprednisolona na dosagem de 40 mg/mL, suspensão injetável (IV), bem como não se recomenda nas formas de 500 mg, pó liofilizado injetável e metilprednisolona 125 mg/mL injetável.