The periodontium is a highly hierarchically organized organ composed of gingiva, alveolar bone, periodontal ligament and cementum. Periodontitis leads to the destruction of hard and soft tissues ultimately leading to a loss of the teeth supporting apparatus. Current treatments are capable of limiting the disease progression; however, true regeneration, characterized by perpendicularly oriented periodontal ligament fibre attachment to cementum on the root surface remains challenging.Tissue engineering approaches have been developed to enhance regeneration via micro-engineered topographical features, purposely designed to guide the insertion of the regenerated ligament to the root surface. This review reports on the recent advancements in scaffold manufacturing methodologies for generating fibre guiding properties and provides a critical insight in the current limitations of these techniques for the formation of functional periodontal attachment. K E Y W O R D Sfibre guiding, multiphasic scaffold, periodontal attachment, periodontitis, tissue engineering

No abstract

No abstract

No abstract

Our work developed a 3D SARS-CoV-2 antibody detection platform in non-invasive saliva samples using S1-RBD protein-immobilized 3D melt electrowritten poly(ε-caprolactone) scaffolds.