Rhizophora apiculata, merupakan jenis tanaman mangrove yang tersebar melimpah di pesisir Indonesia. Populasi tanaman bakau di Indonesia mencapai 75% dari seluruh populasi bakau di dunia. Melimpahnya tanaman ini, belum dimanfaatkan secara optimal. Berdasarkan penelitian terdahulu, diketahui Rhizophora apiculata memiliki beberapa manfaat, salah satunya sebagai antibakteri. Zatantibakteri yang tekandung pada Rhizophora apiculatayaitu tannin, flavonoid dan saponin. Tannin bekerja mengadakan komplek hidrofobik dengan protein, menginaktivasi adhesi, enzim dan protein transport dinding sel, sehingga mengganggu pertumbuhan bakteri. Flavonoid bekerja menghambat sintesis asam nukleat, menghambat fungsi membran sel dan metabolisme energisertamencegah perkembangbiakan bakteri dengan membentuk senyawa kompleks protein ekstraseluler yang akan mengganggu integritas membran sel. Saponin bekerja dengan melisiskan sel bakteri. Berdasarkan penelitian yang telahdi lakukan, ekstrak daun, kulit batang dan akar Rhizophora apiculatadapat menghambat pertumbuhan bakteri Pseudomonas aeruginosa,Staphylococcus aureus, Streptococcus sp, dan Escherichia coli.Tujuandariliterature reviewiniadalah untuk mengetahui potensi Rhizophora apiculatasebagaiantibakteri. Metode yang digunakandalamartikeliniadalahpenelusuran artikel melalui database Google Scholar dan NCBI, lalu artikel dipilih dengan meninjau judul dan abstrak artikel, melibatkan 22 pustaka baik nasional maupun internasional.Hasil dari berbagai penelusuran yang dicantumkan dalam artikel ini untuk menunjukkan adanya potensiRhizophora apiculatasebagaiantibakteri.  Kata kunci: rhizophora apiculata, zatantibakteri, kandunganrhizophora apiculata   EFFECT ANTIMICROBACTERIAL RHIZOPHORA APICULTA FOR INHIBITS GROWTH OF BACTERIA   ABSTRACT Rhizophora apiculata is a type of mangrove that is spread abundantly in the coastal areas of Indonesia. The population of mangroves in Indonesia reaches 75% of the total mangrove population in the world. The abundance of mangroves in Indonesia has not been used optimally. Based on previous research, it is known that Rhizophora apiculata has several benefits, one of them is as an antibacterial. Anti-bacterial substance found in Rhizophora apiculata are tannin, flavonoid and saponin. Tannin works by holding a hydrophobic complex with protein, inactivates adhesion, enzymes and protein transport of cell walls, thereby disturb of bacterial growth. Flavonoids, work to inhibit nucleic acid synthesis, inhibit cells membrane function and inhibit energy metabolism and prevent bacterial proliferation by forming extracellular protein complex compounds that will disturb membrane cell integrity. Saponin as an antibacterial, works by lysis of bacterial cells. Based on several studies that have been done, leaf, bark and roots extracts of Rhizophora apiculata can inhibit the growth of the bacteria Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus sp. and Escherichia coli. Rhizophora apiculata has an effect in inhabiting the growth of certain bacteria.The purpose of this literature review article is to get to know about the potency of Rhizophora apiculata as an antibacterial. The method used in this article uses a review of articles from Google Scholar and NCBI databases, then the article are selected by reviewing the article titles and abstracts, involving 22 libraries both national and international.The results of various articles included in this article are to show the potency of Rhizophora apiculata as an antibacterial.   Keywords: rhizophora apiculata, anti-bacterial substance, content of rhizophora apiculata

Diabetes mellitus was one of WHO priority diseases because the number of sufferers is quite high and always increased in every country, especially in Indonesia. Efforts to manage diabetes mellitus from non-pharmacological, pharmacological, to traditional treatments have been carried out. Indonesia is also a country that has a variety of nutritious plants, but only a few plants have been used as traditional medicine. The purpose of this study was to find out how the utilization would be done using dandelion or Taraxacum officinale for type 2 diabetes mellitus so that the results would be useful to increase knowledge for health providers and the people of Indonesia in utilizing the natural resources in Indonesia. This type of research was a literature review and the method used in this study literature was collecting 21 literature from books and 30 case report and research article journals. Conclusion: One of the medicinal plants found in Indonesia was dandelion plant (Taraxacum officinale) which was known to have antihyperglycemic or antidiabetic effects, but its use in Indonesia was quite rare. Antidiabetic mechanisms of this plant are reabsorption of the glucose in the kidneys, reducing the activity of the enzyme alpha-amylase and alpha-glucosidase, reducing glucose levels in the blood, and inhibiting the flow of potassium channels.