Background: There has been a substantial shift in the educational curriculum in Indian medical institutes with a more experiential approach toward teaching. One such method is case-based learning (CBL). Objectives: This study aimed to compare CBL with traditional method and gain students’ and teachers’ feedback. Methods: This was a cross-sectional study conducted in the Pathology Department among second-year bachelor of medicine and bachelor of surgery (MBBS) students. The students were divided into two groups of 75 students: group A was given anemia cases, and group B was given jaundice cases. After covering theory lectures on these topics, the students were given pre-test multiple-choice questions (MCQs). This was followed by this was followed by subdividing students into five groups and conducting three CBL sessions. This was followed by post-CBL test. Data were compared using paired t-test and analyzed using SPSS software version 16. Results: Out of 150, 110 students attended the pre-and post-CBL test and completed the feedback form. There was a significant improvement (P < 0.001) in the mean scores of students in both groups A and B from 8.31 and 7.54 to 13.44 and 12.71, respectively. Regarding the student feedback, it was revealed that 87% of the students agreed with the usefulness of CBL in better understanding of the topic and retention in memory. They also acclaimed that it encouraged their critical thinking and decision-making qualities. Among the faculties, all of them agreed with the incorporation of CBL in the routine curriculum. Conclusions: CBL improves students’ logical, analytical and clinical skills, which helps bridge the gap between theoretical knowledge and clinical skills. Rather than replacing, it serves better as an adjunct to the traditional lectures.

Plasmablastic lymphoma (PBL) is a rare aggressive subtype of non-Hodgkin's lymphoma with large neoplastic cells. It is usually associated with human immunodeficiency virus (HIV) infection but also identified in patients with solid organ transplantation and in immunocompetent patients. It frequently presents as a mass in oral cavity, but has also been described in other extra-oral sites like gastrointestinal track, skin, genitourinary track, nasal cavity, paranasal sinuses, etc. It is characterized by plasmablastic features and an immunoprofile close to plasma cells, Epstein–Barr virus (EBV) positivity and MYC gene dysregulation. We report a case of a 40 year old HIV positive male who presented with intestinal obstruction having mass in transverse colon. Histopathological examination of the excised mass revealed submucosa and muscularis propria infiltrated by monotonous population of medium to large sized lymphoid cells with plasmacytic differentiation. The tumour cells were immunoreactive for EMA, CD138 and Vimentin and immunonegative for LCA, CK, S-100, Chromogranin, CD20, CD30, CD3. Thus the final diagnosis of Non-Hodgkins Lymphoma – Consistent with Plasmablastic Lymphoma was made. PBL should be carefully differentiated from Plasmablastic Plasma cell myeloma, other CD20 negative B-cell neoplasma i.e. primary effusion lymphoma, anaplastic lymphoma Kinase (ALK)-positive large B-cell lymphoma, large B-cell lymphoma arising in human herpesvirus 8 (HHV-8)-associated multicentric Castleman disease.

Introduction: Non-neoplastic skin disorders encompass a wide spectrum of pathological processes which show age, sex and geographical variation in distribution. Histopathological examination continues to play an invaluable role in diagnosis and management of non neoplastic skin disorders. The present study aims to analyse the histomorphological spectrum of non-neoplastic skin lesions received in a tertiary care hospital, to study their age and sex distribution and to classify the lesions into categories that predict clinically important attributes. Material and Methods: The current study is an observational retrospective study conducted in Department of Pathology in a Tertiary Care Hospital in South Gujrat. 205 skin specimen of non neoplastic skin lesions received over a period of one year (February 2019 to January 2020) were studied. Results: Among 205 cases of non neoplastic skin lesions, male predominance was seen. 21-30 years and 31-40 years were the most common age group. Infectious disorders were the most common category (73 cases) followed by non-neoplastic cutaneous cysts (72 cases). Epidermoid cyst was the common skin lesion closely followed by Leprosy. Borderline Tuberculous was the most frequent subtype of leprosy. Leprosy was most common in 21-30 years age group. Most common vesicobullous disease was Spongiotic Dermatitis followed by Pemphigus Vulgaris. Psoriaform and lichenoid dermatitis showed equal incidence. Conclusion: Heterogeneity in the clinical presentation of skin diseases makes histopathological examination a gold standard technique for final diagnosis. Cutaneous cysts and infectious formed the bulk of cases. Leprosy was the most common non cystic non neoplastic skin lesion of our study.