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Cadmium (Cd) and lead (Pb) are heavy metals which used in many industry and were confirmed as environmental toxin and mainly effects reproductive system and toxic to growing fetus. Determination of cadmium and lead level generally measure by spectrophotometric methods. But in this study, we used a method based on approach adjusting specific gravity. This study aimed to evaluate the potential effect of cadmium and lead exposure on pregnancy outcome by measuring their correlation on renal function. This study was performed between January to May 2013 and targeted 57 pregnant women as the control group (32 patients of normal pregnancy) and case group (25 patients of preeclampsia). For analyzing of the data, SPSS software version 17 was used and was examined by Mann-Whitney test and Spearman correlation test. We found that there are significant correlation between Cd an Pb exposure on urea level, urea-creatinine ratio, and GFR of the pregnancy patients (p < 0,05) but unlike to the creatinine serum. 

 Abstract-Neonatal sepsis is a clinical syndrome in the first months of infant life due to a systemic response caused by the presence of pathogenic microorganisms or their products in the blood. Sepsis promotes the unbalanced production of oxidant and anti-oxidant substances, causing an excess of free oxygen radicals. Early markers of neonatal sepsis have been studied in recent years, and we proposed another parameter to detect early-onset neonatal sepsis with salivary antioxidative index (SAOI), saliva has been shown as blood representatives and to have many benefits. This study was conducted in April -June 2012, saliva specimens were taken from 57 newborns, in which 32 infants were at risk of sepsis and 25 infants were healthy and served as a control group. Data was analyzed by Mann-Whitney test. We concluded that sepsis possibility 3,7 fold when there are low AOI. This parameter may be used as another marker to detect early-onset neonatal sepsis. Index Terms-Early-onset neonatal sepsis, free oxygen radicals, salivary antioxidative index