A combined experimental and theoretical investigation aims to elucidate the necessary roles of oxygen in photoredox catalysis of radical cation based Diels-Alder cycloadditions mediated by the first-row transition metal complex [Cr(Ph2phen)3](3+), where Ph2phen = bathophenanthroline. We employ a diverse array of techniques, including catalysis screening, electrochemistry, time-resolved spectroscopy, and computational analyses of reaction thermodynamics. Our key finding is that oxygen acts as a renewable energy and electron shuttle following photoexcitation of the Cr(III) catalyst. First, oxygen quenches the excited Cr(3+)* complex; this energy transfer process protects the catalyst from decomposition while preserving a synthetically useful 13 μs excited state and produces singlet oxygen. Second, singlet oxygen returns the reduced catalyst to the Cr(III) ground state, forming superoxide. Third, the superoxide species reduces the Diels-Alder cycloadduct radical cation to the final product and reforms oxygen. We compare the results of these studies with those from cycloadditions mediated by related Ru(II)-containing complexes and find that the distinct reaction pathways are likely part of a unified mechanistic framework where the photophysical and photochemical properties of the catalyst species lead to oxygen-mediated photocatalysis for the Cr-containing complex but radical chain initiation for the Ru congener. These results provide insight into how oxygen can participate as a sustainable reagent in photocatalysis.
2,2':6',2″-Terpyridyl (tpy) ligands modified by fluorine (dftpy), chlorine (dctpy), or bromine (dbtpy) substitution at the 6- and 6″-positions are used to synthesize a series of bis-homoleptic Fe(II) complexes. Two of these species, [Fe(dctpy)] and [Fe(dbtpy)], which incorporate the larger dctpy and dbtpy ligands, assume a high-spin quintet ground state due to substituent-induced intramolecular strain. The smaller fluorine atoms in [Fe(dftpy)] enable spin crossover with a T of 220 K and a mixture of low-spin (singlet) and high-spin (quintet) populations at room temperature. Taking advantage of this equilibrium, dynamics originating from either the singlet or quintet manifold can be explored using variable wavelength laser excitation. Pumping at 530 nm leads to ultrafast nonradiative relaxation from the singlet metal-to-ligand charge transfer (MLCT) excited state into a quintet metal centered state (MC) as has been observed for prototypical low-spin Fe(II) polypyridine complexes such as [Fe(tpy)]. On the other hand, pumping at 400 nm excites the molecule into the quintet manifold (MLCT ← MC) and leads to the observation of a greatly increased MLCT lifetime of 14.0 ps. Importantly, this measurement enables an exploration of how the lifetime of theMLCT (or MLCT, in the event of intersystem crossing) responds to the structural modifications of the series as a whole. We find that increasing the amount of steric strain serves to extend the lifetime of theMLCT from 14.0 ps for [Fe(dftpy)] to the largest known value at 17.4 ps for [Fe(dbtpy)]. These data support the design hypothesis wherein interligand steric interactions are employed to limit conformational dynamics and/or alter relative state energies, thereby slowing nonradiative loss of charge-transfer energy.
Inspired by the multielectron redox chemistry achieved using conventional organic-based redox-active ligands, we have characterized a series of iron-functionalized polyoxovanadate-alkoxide clusters in which the metal oxide scaffold functions as a three-dimensional, electron-deficient metalloligand. Four heterometallic clusters were prepared through sequential reduction, demonstrating that the metal oxide scaffold is capable of storing up to four electrons. These reduced products were characterized by cyclic voltammetry, IR, electronic absorption, and H NMR spectroscopies. Moreover, Mössbauer and X-ray absorption spectroscopies suggest that the redox events involve primarily the vanadium ions, while the iron atoms remained in the 3+ oxidation state throughout the redox series. In this sense, the vanadium portion of the cluster mimics a conventional organic-based redox-active ligand bound to an iron(III) ion. Magnetic coupling within the hexanuclear cluster was characterized using SQUID magnetometry. Overall, the results suggest extensive electronic delocalization between the metal centers of the cluster core. These results demonstrate the ability of electronically flexible, reducible metal oxide supports to function as redox-active reservoirs for transition-metal centers.
A Cr-photocatalyzed [4 + 2] cycloaddition between dienes and electron-deficient alkenes is reported, accessed by up to three converging pathways to yield the “meta” adducts.
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