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Aim: The aim of the present study was to determine the meloxicam concentrations in the plasma of goats at different time intervals after its administration by IV route and data were used to determine the different pharmacokinetic parameters and the bioavailability of meloxicam in goats. Materials and Methods:The present study was conducted on 12 to 18 months old, five adult male local goats (Capra hircus) of Assam, with body weight ranging between 10 to 18 kg. All goats were clinically sound and healthy and reared at Goat Research station, Burnihat, Assam. A single dose of meloxicam was administered intravenously into the jugular vein of goats at the rate of 1 mg/kg body weight. Blood samples were analyzed with the help of high performance liquid chromatography (HPLC) system.Results:After single intravenous administration of meloxicam at the dose rate of 1mg/kg, the mean peak plasma level of the drug was 6.538±0.1189 µg/ml at 2 min. The mean elimination half life (t ) and mean distribution half life (t ) were Conclusion:After calculating various pharmacokinetic determinants, dosage regimens were computed for meloxicam in goats, based on minimum effective therapeutic plasma concentration of 0.7 µg/ml.To maintain the minimum effective concentration of 0.7 µg/ml in plasma for 25 hours following iv administration of meloxicam,an initial loading dose of 1.1 mg/kg body weight followed by a maintenance dose of 1mg/kg body weight/day is recommended.

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Alpha-amanitin is considered to be the main toxin present in mushroom species of Amanita phalloides and it is possibly the most deadly of all amatoxins. The aim of this study was to test whether nanocurcumin could revert the hepatic damage in experimentally induced Alpha-amanitin rats, tested with nanocurcumin in following protocols: Group I served as negative control group (PBS @1ml/kg p.o),

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