Pharmacokinetics, tissue residue and plasma protein binding of ofloxacin in goats

Baruah, Himangshu; Roy, Dulal Chandra; Roy, Rohini Kumar; Khonikor, Hirendra Nath

doi:10.4142/jvs.2004.5.2.97

Cited by 11 publications

(15 citation statements)

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“…The drug was detected above the MIC level for up to 8 h after administration. Comparable plasma levels of ofloxacin (14.76 µg.mL -1 ) have been reported 1 min after a single intravenous injection in goats (Baruah et al 2004), but low initial plasma levels (4.26 µg.mL -1 ) were reported in calves (Gaur et al 2004). Ofloxacin was rapidly transferred from the central to the peripheral compartment in water buffalo calves, as is evident from the short distribution half-life (0.09 h ± 0.003 h) and high values of K 12 (4.7 h -1 ± 0.1 h -1 ) and the K 12 /K 21 ratio (3.56 ± 0.32).…”

Section: Discussionmentioning

confidence: 70%

“…(58.9 µg.mL -1 .h) following a dose of 5mg.kg -1 (Baruah et al 2004;Gaur et al 2004). The large Vd area (2.48 L.kg -1 ± 0.18 L.kg -1 ) measured in these buffalo calves indicated extensive distribution of ofloxacin.…”

Section: Discussionmentioning

confidence: 98%

“…It possesses a broad spectrum of activity against a variety of Gram-positive and Gram-negative bacteria, including some anaerobes. Pharmacokinetic studies of ofloxacin after intravenous administration have been conducted in humans (Bethell et al 1996), dogs (Yoshida et al 1998), swine (Son et al 2000), goats (Baruah et al 2004), cattle (Gaur et al 2004), chicken (Kalaiselvi et al 2006) and rabbits (Ahmad et al 2008). However, there is little information available on the pharmacokinetics of ofloxacin in buffalo species.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (<i>Bubalus bubalis</i>)

Ola

Sandhu

Dumka

et al. 2013

J. S. Afr. Vet. Assoc.

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Pharmacokinetics and urinary excretion of an intravenous dose of 5 mg.kg-1 ofloxacin were investigated in water buffalo calves. Plasma concentrations of ofloxacin were determined by high-performance liquid chromatography. Ofloxacin was rapidly distributed from the central to the peripheral compartment as evidenced by a short distribution half-life (0.09 h ± 0.003 h) and high K12 (4.7 h(-1) ± 0.1 h(-1)), and was detected in plasma for 8 h. The large volume of distribution (2.48 L.kg(-1) ± 0.18 L.kg(-1)) obtained in this study indicated high distribution of ofloxacin in water buffalo calves. The elimination half-life, the area under the plasma drug concentration-time curve and total body clearance were 2.11 h ± 0.13 h, 6.20 µg.mL(-1) ± 0.23 µg.mL(-1).h and 0.81 mL.kg(-1).h(-1) ± 0.03 mL.kg(-1).h(-1), respectively. About 18.7% of administered drug was bound to plasma proteins and approximately 32.5% of the administered dose was recovered in urine within 48 h. The results of the study indicated a favourable pharmacokinetic profile of ofloxacin in water buffalo calves, which suggests that ofloxacin may be effective against urinary pathogens in this species.

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Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (<i>Bubalus bubalis</i>)

Ola

Sandhu

Dumka

et al. 2013

J. S. Afr. Vet. Assoc.

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“…This might be because of the high C max and double peaks observed in some birds. Double peaks in fluoroquinolones have been reported in bucks (Takawale et al, 2000) and in goats (Baruah et al, 2004). The double peaks in fluoroquinolones could be attributed to enterohepatic recycling which are characteristic features in this class of drugs (Brown, 1996).…”

Section: Discussionmentioning

confidence: 93%

“…The concentrations of sparfloxacin in plasma were assayed after extraction (Rao et al, 2000), using a modified HPLC method (Baruah et al 2004). To extract sparfloxacin, 450 ml of acetonitrile were added to 300 ml of plasma (1Á5:1, v/v) in a microcentrifuge tube to precipitate the plasma proteins.…”

Section: Assay Proceduresmentioning

confidence: 99%

Pharmacokinetics of sparfloxacin in broiler chicken

Sriranjani¹,

Kalaiselvi²,

Ramesh³

et al. 2006

British Poultry Science

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1. The pharmacokinetics of sparfloxacin in broiler chicken was investigated following a single intravenous dose of 10 mg/kg and a single oral dose of 20 mg/kg. The pharmacokinetic parameters (AUC(0-24) or C(max)) were integrated with the pharmacodynamic parameter (MIC(90)) to optimize sparfloxacin dosage in chicken. 2. The apparent volume of distribution, total body clearance, mean residence time and elimination half-life following oral administration were 2.411/kg, 4.55 ml/min per kg, 10.54 and 5.94 h, respectively. Oral bioavailability was 61.7%. 3. Sparfloxacin was found to possess clinically useful pharmacokinetic properties. Based on pharmacokinetic/pharmacodynamic integration an oral dose of 20 mg/kg sparfloxacin for every 24 h might be recommended for a successful clinical effect in chickens.

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Pharmacokinetic study of ofloxacin enantiomers in Pagrosomus major by chiral HPLC

Nie

Wang

Gao

et al. 2015

Biomedical Chromatography

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(S)-(-)-Ofloxacin and (R)-(+)-ofloxacin concentrations in the plasma of Pagrosomus major after drug treatment were detected by chiral high-performance liquid chromatography, and various pharmacokinetic parameters were calculated from these data. The elimination half-life of (S)-(-)-ofloxacin was significantly shorter than that of the (R)-(+) enantiomer. (S)-(-)-Ofloxacin also had a significantly lower maximum plasma concentration, area under the concentration-time curve from zero to infinity, and mean residence time than (R)-(+)-ofloxacin. However, the apparent volume of distribution and total body clearance of (S)-(-)-ofloxacin were greater than those of (R)-(+)-ofloxacin. The ratio of the (S)-(-)- to (R)-(+)-ofloxacin plasma concentration was always <1.0. Together, these data suggest that (S)-(-)-ofloxacin was preferentially excreted and (R)-(+)-ofloxacin was preferentially absorbed. Although the difference in pharmacokinetic parameters was small, the metabolic behavior of the ofloxacin enantiomers in P. major was enantioselective.

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Pharmacokinetics, tissue residue and plasma protein binding of ofloxacin in goats

Cited by 11 publications

References 0 publications

Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (<i>Bubalus bubalis</i>)

Pharmacokinetics, urinary excretion and plasma protein binding of ofloxacin in water buffalo calves (<i>Bubalus bubalis</i>)

Pharmacokinetics of sparfloxacin in broiler chicken

Pharmacokinetic study of ofloxacin enantiomers in Pagrosomus major by chiral HPLC

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