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Parkinson's disease is a age associated chronic neurodegenerative disorder of central nervous system characterized by selective loss of dopaminergic neurons in substaintia nigra pars compacta which causes functional impairment of midbrain. Although the cause of PD is still not known, but there are several factors such asoxidative stress, genetic mutations, mitochondrial dysfunction, aggregationprotein specifically αsynuclein and neuroinflammation play apivotal role in pathogenesis of PD. The current treatment primarily includes dopaminergic and non-dopaminegic medications which only provides symptomatic relief and when drug therapy is fails to provide relief, the next step is surgical treatments. Unfortunately the current regimens have certain limitations with multiple side effectsand possess economic burden thus, there is a need to discovered new therapeutic approaches which have antiparkinsonial potential and minimum adverse effects. For many years, some phytoconstituents from natural products have provided an competent resource for the revelation of potential therapeutic agents. The anti-PD potential of these phytoconstituents is because of their well apperceived anti-oxidative, anti-inflammatory activities, their repressive role on agreegation of protein and the regulatory effects of PD cognate pathways. The intention of this review article is to cover the potential of phytoconstituents against the neurodegeneration intangle in PD and to encourage the improvement in future novel treatment strategies predicated on natural sources.

Parkinson's disease (PD) is age associated neurodegenerative disorder of the central nervous system. The PD is marked by selective degeneration of dopamine neuron in the specific part of brain called substaintia nigra which leads to several motor and non-motor symptoms. The cause of diseases rests uncertain, however the factors like oxidative stress, aggregation of alpha-synuclein protein, mitochondrial dysfunction, neuroinflammation and many others contribute in development of Parkinson's disease. The current available pharmaco-therapeutics, focused on replenishing the striatal dopamine level but none of them able to halt disease progression. The existing treatment is hindered by the definite boundaries such as it fails to cure disease, provide only symptomatic relief, safety issues and cost of treatment is also more. As the existing treatments are hindered by therapeutic restrictions and with certain adversarial effects; thus, there is a requirement to improve fresh in addition other operative medications with less adversarial effects. The purpose of present manuscript is to explore the capability of phytoconstituents with neuroprotective assets counter to neurodegeneration concerned in PD and encourage expansion of future novel management approaches supported by natural sources.

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