AimThe present study was designed to investigate the association of ABO blood group types in cervical cancer. Material and MethodsThe study sample consisted of 248 subjects as confirmed cases of cervical cancer and 254 individuals as controls. Data about the blood group types was collected from the blood bank of Govt. Medical College, Jammu. ResultsA statistical significant difference in the distribution of ABO blood groups between the patients and controls was observed. The incidence of B-type group was the highest in the patients as well as in the control subjects this was followed by O blood group. ConclusionThe results concluded that B blood group may be considered as a risk factor in carcinoma of the cervix.

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FISH results of CEP 3 in the present study showed the frequent gains of chromosome 3 in Squamous cell carcinoma over the chromosome 17. ANOVA results were found to be significant for both CEP 3 and CEP-17 in Squamous cell carcinoma of the cervix. Chi square test (disease v/s control) was also used to study the significant difference between the patients and the controls and it was found to be significant for both chromosomes 3 and 17.

Aneuploidy was the most common numerical chromosomal aberration recorded in the majority of the tumor growths. Structural aberrations included translocations and deletions. Non-cytogenetic factors like multiparity, early marriage, poor genital hygiene and rural background were highly prevalent in the present study.

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