This study has shown that propolis is a promising bioactive component in dental products, especially for use in Cariology and Periodontology. Although there has been significant progress in applications of propolis, the field of dental products is still a growing area and it is important to encourage innovation and development of new products incorporating propolis based on knowledge of its composition and therapeutic properties.

Background: Copaiba oil-resin has been widely used and is especially found in neotropical regions, for which several pharmacological activities have been documented over the years. Prospective studies in intellectual property banks are important to increase competitiveness and thus generate new products in various research areas. Objective: A prospective study was carried out on patents of products containing copaiba oil-resin for dental use in intellectual property banks. Methods: The research was conducted with patent searches in six intellectual property banks of the world. Relevant information about the invention in the patent document was collected, processed and described. Results: The search found 9 patents using copaiba resin oil-resin in dental products. The National Institute of Industrial Property (INPI-Brazil) had the highest number of deposits (5), followed by Espacenet (2) and Free Patents (2). C. Langsdorffii was highlighted as the most widely used species in the products and deposits of vehicles in formulations (3). All the patents in the search are A61K code for medical, dental or hygienic purposes. Conclusion: Most of the found patents are related to the area of Microbiology, specifically with application in Cariology. Brazil is represented by the INPI and presented the highest number of patent applications when compared to other intellectual property banks.

Purpose. This study aimed to evaluate reports of patents for oral care formulations, based on Camellia sinensis (C. sinensis), deposited and granted in intellectual property banks. Methods. A survey was conducted through collection, treatment, and analysis of extracted information from patent reports selected. The documentary research was conducted in January 2021 on formulations with C. sinensis for dental applications, including since the first patent deposits until the current time. The risk of bias of clinical trials with these formulations was analyzed to verify the scientific evidence. The data extracted represent the distribution of the number of patents by banks, annual evolution of patent deposits, applicant of patents by country, distribution of patents according to International Patent Classification codes, and the types of patented products. Results. Data and information from 20 selected patents were extracted. The United States Patent and Trademark Office (USPTO) and World Intellectual Property Organization (WIPO) were the banks with the largest number of patents for products/formulations with C. sinensis for oral care applications with 7 (35%) and 6 (30%) patent registrations, respectively. Other banks did not provide patents related to the search. Patents of compositions were the largest with 14 filings, and the remainder of formulations are represented specially by mouthwashes and toothpastes. As for clinical application, 18 patents were filed as products with antimicrobial and antibiofilm action, while 2 patents are directed to the treatment of xerostomia. In general, the aspects of the studies of clinical efficacy pointed to a low risk of bias. Conclusion. The study pointed out a small number of products protected by patents for Camellia sinensis for oral care indication, highlighting mainly mouthwash compositions and formulations. In the methodological parameters of clinical trials carried out with the formulations, the majority pointed out a low risk of bias.

The social determinants of health directly influence in the health-disease process. In the pandemic caused by the novel Coronavirus, denominated Coronavirus Disease 2019 (COVID-19), these factors imply the transmission and worsening of the disease. This work is aimed to correlate the social vulnerability in Brazilian regions with the number of COVID-19 confirmed cases. The analysis was made through a qualitative approach in the search for information made available by public agencies such as the Brazilian Institute of Geography and Statistics (IBGE), State Department of Health, Municipal Department of Health and the literature indexed on the Scientific Electronic Library Online (SciELO) database using the health descriptors: “Social determinants of health”, “Health-disease process”, “Social vulnerability” and “COVID-19”. As results, the discrepancy between regionals incidence and mortality rates suggests a relationship with social inequality and COVID-19 indices in the regions of Brazil. North and Northeast had the worst rates in most of the evaluated parameters. Therefore, the vulnerable population of fundamental resources for dignified survival is more susceptible to aggravations and failures in coping with new infectious diseases.

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