Successful human tissue adhesives depend on sure parameters which cannot be matched by any one adhesive. In this work, the novel human tissue adhesive is fabricated from gelatin and coconut shell carbon nanopowder composite. Characteristics of the carbon powder and the product samples were then investigated by X-ray diffraction (XRD), scanning electron microscopy (SEM). Mechanical characterization and tissue adhesive bonding test of the final product were also performed.

The topical hemostatic agents in surgery are biomaterials that very important for surgeons to stop bleeding in the complicated areas. Currently available hemostatic agents are often expensive, ineffective or raise safety concerns. Synthetic rice starch-based sponge was an inexpensive and promising alternative. In this study, we synthesized and characterized a new hemostatic agent from rice starch and investigated their use as a hemostatic material. The rice starch-based sponge having interconnected pore were synthesized via blending of the rice starch and additive of carboxymethylcellulose (CMC), polyvinyl alcohol (PVA), and glycerol in hot water, freezing and drying by vacuum sublimation with enlarged porosity and rapid swelling behavior. Characteristics of the final products were then investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD) and scanning electron microscopy (SEM-EDS). In vivo studies using 4 rabbits with liver injury showed rice starch-based sponge blood aggregate formation as well as bulk blood coagulation inhibition. The biocompatibility tests showed that this sponge is safe and effective after follow-up for at least 6 months of animal and clinical trial.

Rice-based gel is intended to be a coupling agent for usage in ultrasonic application, which made from blending of rice starch powder, sodium hydroxide, carboxymethyl cellulose, glycerin, and water. In this study we test the products for safety and efficacy in 100 patients, by four physicians. The imaging results revealed that, when compared with standard ultrasound gel, rice gel can produce equal clearness but with better echogenicity. So, rice-based ultrasound gel should be an alternative choice for general hospitals.

Novel rice gels were prepared with different compositions of rice starch (RS) powder and solution of additives. The formulations of gels were composed of RS powder, liquid glycerol, and additives by aqueous solution method. Five solution with different concentration of RS powder (0.5 g, 1 g, 1.5 g, 2 g and 2.5 g). These solutions were dried in electric oven at 65°C for 4 hours. The physical and chemical properties of rice gel characterized were: turbidity, viscosity, smell, irritation, cleaning, pH and moisture content of these gels have been monitored. Results showed that 2 g of RS powder was optimized formulation which had turbidity, high viscosity, pleasant smell, non-irritation and easy to clean. The pH value of this gel was 6.92 ± 0.01 and the moisture content was 0.21 ± 0.07 % which was equivalent to commercial standard of ultrasound gel. These results concluded that the application of RS in gel ultrasound was safe and effective for replacement commercial gel ultrasound. This gel should be studied on image quality in ultrasound examination next step.

Rice starch (RS) and carboxymethyl cellulose (CMC) are natural polymers that can be widely used for numerous biomedical applications such as hydrogels, capsules, drug delivery system, wound dressing. The purpose of this study was to prepare and investigate the appropriate weight ratio of RS/CMC blend films by solution casting technique. The swelling ratio and solubility were evaluated. The mechanical properties, intermolecular interaction, and morphology were also analyzed by the universal mechanical testing, Fourier transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM), respectively. The results indicated that the suitable ratio of RS/CMC blend film was 60/40. The swelling ratio, solubility, tensile strength, and elongation at break were 46.8±0.3 times, 21.63±0.72 %, 30.4±1.5 MPa and 5.76±0.31 %, respectively. Moreover, the physical linkages exhibited mainly between the hydroxyl groups of RS and the carboxyl groups of CMC. In addition, the cross-sectional SEM images of blended films showed the miscibility of RS and CMC. This study suggested that the RS/CMC blended film can be used as a hemostatic film.