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Cardiovascular pathology in patients with superinvasive opisthorchiasis is characterized by severe changes in haemodynamics and myocardial metabolism, impaired automatism, excitability, and conduction of the heart muscle. An analysis of 578 cases (medical and outpatient records and reports of pathoanatomical and forensic autopsies) recorded in healthcare facilities treating opisthorchiasis patients with a hyperendemic focus was carried out. We identified a set of cardiac changes in patients with hypereosinophilic syndrome associated with superinvasive opisthorchiasis infection, classified the pathological processes in accordance with ICD-10, and described their pathogenesis.

Clinical and experimental studies have shown that opisthorchii tend to evade tumour growth foci to colonize more distant areas of the liver. When modelling tumours with various carcinogens in the setting of superinvasive opisthorchiasis, the intensity of invasion is reduced both before the formation of neoplasms (>120 days) and after the development of tumours of various histogeneses (liver, pancreas, and stomach) (>240 days). Egg production was observed to increase with the decrease in the number of parasites in the liver. The smallest changes in the infestation intensity indicators and egg production were observed in the experimental stomach tumours (p>0.05). A partial hepatectomy in the setting of opisthorchiasis did not affect the number of parasites in the ecological niche (liver) or the production of eggs by the helminth. With the deterioration of the vegetation state, parasite clumps of opisthorchii increase egg production under the conditions of distress.

Opisthorchiasis is a parasitic disease that represents a serious medical and social problem for the population living in the area of vegetation of opisthorchis larval stages. The parasitic disease significantly reduces the activity and potential of the indigenous and newcomer population of hyperendemic hotbeds. Wild and domestic animals are actively involved in maintaining the epidemiological tension of the hotbeds, among the latter, cats and dogs infected with opisthorchiasis, in which the pathomorphology of the liver and oncogenesis have not been studied, are of great importance. On the basis of sufficient factual material, this gap has been partially filled in this work. Aim. To determine the features of pathomorphological transformations of the liver and pancreas in spontaneous opisthorchiasis in cats and dogs, to identify the possibility of oncogenesis against the background of superinvasive opisthorchiasis (SO) in synanthropic animals of a hyperendemic hotbed. Material and methods. The pathomorphology of the liver and pancreas in 48 animals was studied. The specimens were processed by histological, histochemical methods, the indices of the area of inflammatory infiltrates, granulomas, necroses were calculated, the indicators were subjected to statistical processing. Results. In superinvasive opisthorchiasis, cats and dogs develop a complex of structural proliferating transformations characteristic of other hosts of the parasite – humans, laboratory animals. In synanthropic animals, against the background of SO, the development of malignant neoplasms is possible. Conclusion. Superinvasive opisthorchiasis in synanthropic animals causes permanent proliferation of progenitor cells of the liver and pancreas, which provides the promotor effect of oncogenesis in the liver – the main econiche of Opisthorchis felineus vegetation.

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