Cardiovascular pathology in patients with superinvasive opisthorchiasis is characterized by severe changes in haemodynamics and myocardial metabolism, impaired automatism, excitability, and conduction of the heart muscle. An analysis of 578 cases (medical and outpatient records and reports of pathoanatomical and forensic autopsies) recorded in healthcare facilities treating opisthorchiasis patients with a hyperendemic focus was carried out. We identified a set of cardiac changes in patients with hypereosinophilic syndrome associated with superinvasive opisthorchiasis infection, classified the pathological processes in accordance with ICD-10, and described their pathogenesis.

various higher educational establishments, in preparation for introduction of mobile technology into educational process. Therefore it permits to diagnose the status of the theme. Design/methodology/approaches: The applied methodology consists of the theoretical analysis of scientific literature on problems of mobile learning of students. The concept «mobile learning» was categorically characterized as a component of more general category – «educational technology». The sociological research among students of higher educational institutions was conducted and recommendations were made. Findings: During the theoretical analysis and the practical research it has been revealed that students use the mobile device to educational process insufficiently, considering the high level of its technical facilities. Nevertheless, almost all of the students are ready to introduction of mobile learning as the main form of education. The received results show that mobile learning effectively takes root into educational life of students. Originality / Value: According to the opinion of the authors, the use of smartphones and laptops in the educational process will begin to increase year by year in the nearest future and give to student an opportunity of a choice of technology of education.

Opisthorchiasis is a parasitic disease that represents a serious medical and social problem for the population living in the area of vegetation of opisthorchis larval stages. The parasitic disease significantly reduces the activity and potential of the indigenous and newcomer population of hyperendemic hotbeds. Wild and domestic animals are actively involved in maintaining the epidemiological tension of the hotbeds, among the latter, cats and dogs infected with opisthorchiasis, in which the pathomorphology of the liver and oncogenesis have not been studied, are of great importance. On the basis of sufficient factual material, this gap has been partially filled in this work. Aim. To determine the features of pathomorphological transformations of the liver and pancreas in spontaneous opisthorchiasis in cats and dogs, to identify the possibility of oncogenesis against the background of superinvasive opisthorchiasis (SO) in synanthropic animals of a hyperendemic hotbed. Material and methods. The pathomorphology of the liver and pancreas in 48 animals was studied. The specimens were processed by histological, histochemical methods, the indices of the area of inflammatory infiltrates, granulomas, necroses were calculated, the indicators were subjected to statistical processing. Results. In superinvasive opisthorchiasis, cats and dogs develop a complex of structural proliferating transformations characteristic of other hosts of the parasite – humans, laboratory animals. In synanthropic animals, against the background of SO, the development of malignant neoplasms is possible. Conclusion. Superinvasive opisthorchiasis in synanthropic animals causes permanent proliferation of progenitor cells of the liver and pancreas, which provides the promotor effect of oncogenesis in the liver – the main econiche of Opisthorchis felineus vegetation.

Purpose of the study. The aim of the research is to develop new approaches of improvement the level of training of IT-specialists with knowledge and skills that are in demand on the labor market. The proposed methodology for determining the competencies of IT specialists most in demand by employers includes determining the structure of demand for the competencies of IT specialists in Russia in the digital economy using the developed application. The application of the methodology for the analysis of the content of the academic discipline will make it possible to formulate recommendations on the selection of software tools and technologies used to teach students practical skills in this discipline based on the current requirements of the labor market.Materials and methods. The main idea of the research is to develop a universal methodology that allows you to coordinate the content of the theoretical and practical components of academic disciplines with dynamically changing qualification requirements for specialists in the IT industry from employers. The study of existing approaches to determining the qualification requirements for IT industry specialists has shown that the most effective methodology can be based on the analysis of large volumes of statistical data, the use of modern methods of analysis Data mining, Text mining, and the use of databases to store the collected information. The article discusses a comprehensive methodology for collecting and analyzing information collected from the websites of recruiting companies, including: 1) an algorithm for determining the competencies of IT specialists most in demand by employers; 2) a database model for storing information about vacancies; 3) an algorithm for bringing unstructured textual information about a vacancy to a factual database; 4) authoring analytical application based on the Qlik Sence BI system, which allows monitoring vacancies. The novelty of the proposed approaches lies in the possibility of operational updating of the content of academic disciplines based on labor market requirements.It is proposed to define the indicator of the demand for professional competence (demand for specialists who own IT technology) as the ratio of the number of vacancies in which this competency is mentioned to the total number of vacancies in potential areas of graduate work. It is obvious that those competencies that will show the best results and are in demand on the labor market.Based on an analysis of the requirements of employers for applicants posted on the website of the Russian company HeadHunter, an example of determining the current competencies in the field of database technologies is considered. An analytical application developed on the basis of the Qlik Sence BI system was used as a tool. Information was collected using the Datacol parser (module “parser resume hh.ru”).Results. In general, the proposed methodology can be used to analyze the relevance of software tools used to teach students practical skills within the academic discipline. The specific results obtained as a result of the study can be useful in the formation of a workshop for teachers of such disciplines as “Databases”, “Database Management Systems” and other disciplines in this area.Conclusion. In the conditions of the dynamic development of the sphere of information technology, constant updating of the disciplines of this profile is a prerequisite for the quality training of IT specialists. The article proposes a methodology for choosing software products used for teaching students based on current labor market requirements. The article is based on the results of scientific and practical development “Development of new approaches to the preparation of ITspecialists in the Plekhanov Russian University of Economics, taking into account the requirements of employers”, carried out as part of an internal Plekhanov Russian University of Economics grant. According to the results of scientific and practical development, a certificate of registration of a computer program was received.

The model for the formation of the readiness of pre-service music teachers to the introduction of music-pedagogical technologies is developed, it includes elements: methodological-targeted; content-technological; productive-evaluative. The created model of the use of music-pedagogical technologies in lessons of musical art in secondary schools contains music perception, vocal-choral work, improvisation, playing on musical instruments, and musical-plastic activity.