The purpose of this work was to investigate renal blood supply disturbance in patients with chronic renal disease stage I-II (pyelonephritis, glomerulonephritis, diabetic nephropathy). Material and methods. The authors carried out 131 complex ultrasonic investigations using ultrasonic duplex color kidney scanning. 47patients with chronic pyelonephritis (ChPN), 48patients with diabetic nephropathy stage IV (DN) and 36patients with chronic glomerulonephritis (ChGN) were involved into investigation. Each group consisted of 2 subgroups – with arterial hypertension (AH) and without AH. 20 healthy persons were examined as well. Results. Scantyintrarenal blood flow which is characterized with a decrease of maximal systolic (Vs), minimal diastolic blood velocity(Vd), as well as a decrease of indices of the averaged, according to time, maximal blood velocity (TAMX) and volumetric blood velocity (Vvol) and an increase of index resistance (IR) have been revealed in patients with chronic renal disease (ChRD) stage I-II with the presence of AH stage II. Indices of the vascular renal blood flow under study correlated with the main factors of ChRD progression – glomerular filtration rate (GFR) and daily proteinuria. Conclusion. Reliable Vs, Vd, TAMX and Vvol decrease and a reliable IR increase may be considered as early noninvasive criteria of ChRD progression with the presence of AH stage II.

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Ключові слова: спірометрія, хронічне обструктивне захворювання легень, бронхіальна астма, синдром подразненого кишківника. Клінічна та експериментальна патологія Т.18, №4 (70). С.36-42.

the study aimed to investigate the relationship between red blood cell membrane disorders and Doppler ultrasound indices of renal blood flow in patients with chronic kidney disease (CKD) stages1-2. Methods. The complex clinical, laboratory and instrumental (color duplex Doppler scanning of renal parenchyma vessels) examination was conducted in 131 CKD stage 1-2 patients. Among them, there were 47 patients with pyelonephritis, 48 patients with diabetic nephropathy, and 36 patients with primary glomerulonephritis. Each patients’ group was divided into 2 subgroups: with and without arterial hypertension. Twenty healthy volunteers were also included for the study control. Results. A significant correlation between indices of the erythrocytes morphology and basic Doppler ultrasonography parameters of the kidney vessels circulation, namely a.interlobaris was demonstrated in CKD patients with arterial hypertension. The most significant changes were observed in diabetic patients. Conclusion. The results of our study indicated a high informative value of renal Doppler ultrasonography as a non-invasive technique to diagnose the CKD progression in patients with comorbid hypertension

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