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Nanoscience promises to transform today's world in the same way that integrated semiconductor devices transformed the world of electronics and computation. In the post-genomic era, the greatest challenge is to make connections between the structures and functions of biomolecules at the nanometre-scale level in order to underpin the understanding of larger scale systems in the fields of human biology and physiology. To achieve this, instruments with new capabilities need to be researched and developed, with particular emphasis on new levels of sensitivity, precision and resolution for biomolecular analysis. This paper describes an instrument able to analyse structures that range from tenths of a nanometre (proteins, DNA) to micron-scale structures (living cells), which can be investigated non-destructively in their normal state and subsequently in chemical- or biochemical-modified conditions. The high-resolution scanning Kelvin nanoprobe (SKN) measures the work-function changes at molecular level, instigated by local charge reconfiguration due to translational motion of mobile charges, dipolar relaxation of bound charges, interfacial polarization and structural and conformational modifications. In addition to detecting surface electrical properties, the instrument offers, in parallel, the surface topographic image, with nanometre resolution. The instrument can also be used to investigate subtle work function/topography variations which occur in, for example, corrosion, contamination, adsorption and desorption of molecules, crystallographic studies, mechanical stress studies, surface photovoltaic studies, material science, biocompatibility studies, microelectronic characterization in semiconductor technology, oxide and thin films, surface processing and treatments, surfaces and interfaces characterization. This paper presents the design and development of the instrument, the basic principles of the method and the challenges involved to achieve nanometric resolution and sub-millivolt sensitivity, for both the topographic imaging of surface micromorphology and surface potential and work-function determination.

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This paper describes several electromagnetic sensing arrangements for measuring the percentage of austenite, which has transformed into ferrite in hot rolled steel as it cools. The results from laboratory experiments are presented. These indicate that all the sensors produce outputs, which are associated with the percentage transformation. Using the knowledge gained from this work it is proposed to build an on-line trial sensor for use in a hot strip mill.

This article describes the basic principles of the Hall effect and how it has been applied in solid state applications to measure both the magnetic field and material properties. This is followed by an outline of research undertaken in aqueous ionic solutions as a possible precursor to application in chemical studies. However, previous research has shown that factors such as the Nernst effect have reduced the success of reliably measuring the Hall voltage under these conditions. The possibility of a multi-sensing approach using both electrical and acoustic Hall voltages to overcome these challenges is discussed. The article concludes with a brief look at some early efforts to detect biomolecular interactions.