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A 63-days indoor feeding trial was conducted to assess the growth performance of Labeo rohita fingerling (69.82±0.53 g) fed with three experimental diets containing black thorn, Kaempferia galanga as natural attractant, yeast as probiotic and their combination. Comparable feed consumption in groups fed with attractant (86.54 g) and combination of attractant and probiotic (85.17 g) compared to group fed probiotic only (74.10 g) were observed. Combined use of attractant and probiotic in the diet resulted in highest percent live weight gain (105.30%) compared to the individual inclusion of attractant (60.88%) and probiotic (72.63%). Comparison of feed conversion ratio (FCR) indicated better conversion when fed with the diet containing both the attractant and probiotic (3.69) compared to the other diets containing either probiotic (4.96) or attractant (5.20). Further, highest accretion of carcass protein was recorded in groups fed diet with combination of additives (254.79%), followed by attractant (193.03%) and probiotic (159.29%) alone. RNA/DNA ratio in both liver and muscle exhibited a significant (P<0.05), linear increase in groups fed diet with only probiotics followed by attractant alone, and the combination of both probiotics and attractant accordingly. Present study revealed better efficacy of feed supplemented with Kaempferia galanga in feed consumption, growth promotion and utilization in L. rohita fingerlings, as compared to that with probiotic.However, the combination of probiotics and attractant could confer the better results as compared to their individual dietary inclusion.

Supplementary Figures 1-4 from Activation of Src by Protein Tyrosine Phosphatase 1B Is Required for ErbB2 Transformation of Human Breast Epithelial Cells

<div>Abstract<p>Protein tyrosine phosphatase (PTP) 1B plays a major role in inhibiting signaling from the insulin and leptin receptors. Recently, PTP1B was found to have an unexpected positive role in ErbB2 signaling in a mouse model of breast cancer, but the mechanism underlying this effect has been unclear. Using human breast epithelial cells grown in a three-dimensional matrix, we found that PTP1B, but not the closely related enzyme T-cell PTP, is required for ErbB2 transformation <i>in vitro</i>. Activation of ErbB2, but not ErbB1, increases PTP1B expression, and increased expression of PTP1B activates Src and induces a Src-dependent transformed phenotype. These findings identify a molecular mechanism by which PTP1B links an important oncogenic receptor tyrosine kinase to signaling pathways that promote aberrant cell division and survival in human breast epithelial cells. [Cancer Res 2009;69(11):4582–8]</p></div>