AbstractThe work was dedicated to investigation of dynamics of epileptic activity in conditions of extremely high frequency electromagnetic waves (EHF) radiation (7,1 mm, 0,1 mW/cm2) upon focal epileptic activity. Epileptic activity was penicillin-induced (10,000 IU/ml) in the frontal region of the brain cortex in myorelaxed and artificially ventilated rats under acute experimental condition. Thermal effects were absent as far as absorbed dosage of energy did not exceed 0,1 J/ animal. It was established that preliminarily performed hypogeomagnetic period (3,0 h) with the inductivity of geomagnetic field at 5×10−8 Tesla caused the intensification of antiepileptic effects of EHF (15,0 min of exposure). It was pronounced in the form of decrease of foci intensity and significant reduction of lifespan of foci — up to 115,3±13,4 minutes, which was both significant when compared with separate effects of hypogeomagnetic influence (187,3±12,5 min) and EHF (15,0 minutes of exposure) effect (164,2±12,5 minutes) (P<0,05). Besides, EHF (15,0 min) which was made after 3,0 h exposure to hypogeomagnetic influence suppressed generalized seizures in amygdalarly kindled rats.

In experiments on rats subjected to a procedure of corazole kindling with the development of antiepileptic drug-resistant seizures, we found that manifestations of resistance were suppressed under conditions of feeding the rats with a ketogenic diet (KD) including 80% lipids and 16.6% proteins. Against the background of using this diet, such means as electrical stimulations of the paleocerebellum, irradiation with extremely high-frequency electromagnetic waves (length 7.1 mm), and administration of L-histidine (300 mg/kg) were more effective from the aspect of inhibition of the above seizure activity. At the same time, keeping rats on the KD modified the action of L-arginine on the epileptic activity to a significantly weaker extent.

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