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Background: Rapid developments in the telephone technology made the communication faster and easier. The duration of the use of mobile phones also increased beyond the limitation, and has raised public concerns about their safety. This study is designed to investigate the long term exposure of 1900 MHz to 2200 MHz radiations effect emitted from the third generation (3G) mobile phone in mice liver at histological and biochemical level.Materials and Methods: With approval from institutional animal ethics committee, 36 mice were exposed to 3G mobile phone radiation, 48 minutes per day for a period of 30 -180 days. The control group (36 mice) was kept under similar conditions without 3G exposure. The animals were sacrificed and the liver was removed from first month to six months period. 1ml of blood was collected for SGOT and SGPT analysis. Liver was processed for antioxidant enzyme activity -SOD & GPx, and for routine histological study. The serial sections were analysed under microscope for structural changes. Two groups' data were compared and analysed statistically. Results:In comparision to control group the liver of 3G exposed groups showed the following changes: parenchyma and the periportal regions were infiltrated with inflammatory cells. Focal haemorrhages in the liver parenchyma dilated and congested hepatic sinusoids. Swollen hepatocytes with pyknotic nuclei and vacuolations in the cytoplasm were the significant changes. Biochemical parameters did not show any variable difference. Conclusion:The long term exposure of ultra-high frequency radiation emitted from a 3G mobile phone could cause microscopic structural changes in the liver.

Background and aims: Rapid developments in the telephone technology has made the communication faster and easier. The duration of the usage of mobile phones has also increased beyond the limits, which has raised the public concerns about their safety. This study was designed to investigate the long term exposure of 900 MHz to 1800 MHz mobile phone radiation induced structural changes in the mice liver at histological level. Materials & methods: After approval of institutional animal ethics committee, 36 mice were exposed to 20 (900-1800 MHz) mobile phone radiation, 48 minutes per day for a period of 30 to 180 days. The sham exposed group of 36 mice were kept under similar conditions without 20 exposure. The animals were sacrificed and the liver was removed after 1-6 months. The weight and volume of liver were recorded and the liver tissue was processed for histological study. The sections were studied under light microscope for structural changes. Two groups' data were compared and analyzed statistically. Results: Liver of 20 exposed groups showed the following findings in comparison to sham exposed group: Liver parenchyma and the periportal regions were infiltrated with lymphocytes, macrophages and neutrophil (mixed type of inflammation). Focal hemorrhages were found within the liver parenchyma. Hepatic sinusoids were congested and dilated. Many hepatocytes were swollen and showed pyknotic nuclei and vacuolations present in the cytoplasm. Conclusion: The long term exposure of ultra-high frequency radiation emitted from 20 cell phone can cause microscopic changes in the liver.