Actuality: The amount of pregnant women having periodontal diseases is approximately 40% [1, p. 118]. Usually, such oral diseases as caries, gingivitis, and periodontitis have a great potential to impact on pregnancy outcome. These diseases are interrelated, with progression from supragingival plaques to subgingival infections and periodontal disease [2, p. 447]. Gram-negative anaerobic microorganisms play a leading role in the development of periodontal disease. In patients with untreated periodontal disease, brushing teeth, daily chewing or dental manipulations can cause bacteremia [3, p. 509]. Toxins of subgingival microbial biofilms and proinflammatory cytokines of the diseased periodontium reach the bloodplacental barrier [4, p. 342]. Chemical mediators of inflammation play an important role in the pathogenesis of preeclampsia, intrauterine growth retardation and premature birth [5, p. 1430]. Since that time, three addi-

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