Хронический остеомиелит челюсти как проявление онкогематологической патологии в пожилом возрасте Федеральное государственное автономное образовательное учреждение высшего образования «Белгородский государственный национальный исследовательский университет» (НИУ «БелГУ»), ул. Победы, д. 85, г. Белгород, 308015, Российская Федерация Автор для переписки: Ю.И. Журавлев

In the investigation that was performed, the authors studied the structure and properties of lymphocytes' surfaces in patients with chronic lymphoblastic leukemia with application of atomic force microscopy technology. It was stated that development of chronic lymphoblastic leukemia is characterized with circulation of immature forms of lymphocytic series in peripheral bloodstream, for which increase of surface potential by 456% (p<0.05) as compared with control group, is typical. Surface relief of abnormal cells is characterized by abundance of globular structures with reduced height, which endows it with relief view. Stiffness of lymphocytes in patients with lymphoblastic leukemia is reduced by 51.4% (р<0.05) as compared with control group. Revealed peculiarities of morphological and functional properties of abnormal cell clones lead to microcirculatory embarrassment in vessels, which should be considered at providing standard treatment schemes.

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Shamray E. A., Ryadinskaya A.G., Belyaeva S.S AbstractThe authors studied the features of relief surface and elastic properties of lymphocytes in patients with acute myeloblast leucosis (AML) and chronic myeloblast leucosis (CML) on the stage of the treatment with the method of atomic force microscopy. In patients with AML, there was noted an increase of stiffness of cells by 64% (p <0.05) accompanied by a reduction in the number of globules and recesses on the lymphocytes membrane, and an increase in their height and width as compared with the control group. In patients with CML, the authors observed an increase of Young modulus by 123% (p<0.05) and an increase in the number of globules on the surface as compared with healthy people. The revealed features have an important meaning for understanding the pathogenesis of lymphoproliferative diseases.