No abstract

Apoptosis plays an important role in the development of acute inflammatory lung injury (AILI) and its consequences, which can be realized in different cells with distinct intensity and rate. The aim of this study was to determine the distribution and expression intensity of apoptosis markers in the lungs of rats in the AILI model with endotracheal introduction of capron thread and LPS. Immunoblotting and immunohistochemical studies were performed using monoclonal antibodies against Bax and caspase-3 proteins. It was shown that Bax level increased significantly with the peak on the 7th day. The second peak of Bax 40 dimeric form was noted on the 21st day. The level of both pro-caspase-3 and active caspase-3 was also dramatically increased with a maximum on the 5th day and the second peak of active caspase-3 content was observed on the 21st day. These changes reflected the activation of apoptosis in key trigger periods of AILI during the development of exudative hemorrhagic pneumonia and subsequent fibrotic remodeling of the lungs. Keywords: AILI, apoptosis, Bax, caspase-3, lipopolysaccharide

The review provides up-to-date data on the medico-social significance and scientific aspects of traumatic brain injury (TBI), in particular, the processes of neuroinflammation and the development of autoimmune reactions. According to the results of the analysis of open literature (PumMed database), it is established that among persons of working age, TBI holds the first place in the mortality structure, which is 2-3 times higher in Ukraine than similar indicators of economically developed countries. Each year, TBI costs the world economy about $ 400 billion, which is 0.5% of the gross world product. From a scientific point of view, TBI can be regarded as a continuous, possibly lifelong, process that affects multiple organ systems and can be a cause of traumatic disease. The main pathogenetic mechanisms of TBI that successively change each other (necrosis, axonal damage, gliosis/microgliosis, apoptosis, demyelinization and neuroregeneration) are highlighted.

No abstract

No abstract