Background<br />Smoking is the act of introducing toxic substances into the body. Cigarette smoke contains chemicals that may cause several disorders, including cardiovascular disease, cancer, and chronic obstructive pulmonary disease. Toxic substances in cigarette smoke have the potential to increase free radicals, malondialdehyde (MDA) levels and to decrease endogenous antioxidant (glutathione/GSH) levels. This study aims to determine the relationship of smoking with plasma GSH and MDA levels in medical students.<br /><br />Methods<br />This study was analytical observational with cross-sectional approach. The study was conducted from April to December 2015. The subjects in this study were medical students, consisting of 20 smokers and 20 nonsmokers. Plasma GSH and MDA levels were determined biochemically using Sigma GSH Assay Kit and Sigma MDA Assay Kit. Data was analyzed using the independent t test. <br /><br />Results<br />The results showed that there was no significant difference between mean GSH in smokers (1.74 ± 0.91 mmol/L) and nonsmokers (2.42 ± 1.19 µmol/L) (p=0.441). Mean smokers MDA level of 2.06 ± 1.39 nmol/mL was not significantly different compared with mean nonsmokers MDA level (1.32 ± 0.90 nmol/mL) (p=0.092).<br /><br />Conclusions<br />Smoking tends to decrease plasma GSH levels and increase plasma MDA levels in medical students. Smoking history could be evidence of oxidative stress and an impaired oxidant defense system. In particular, young smokers should quit promptly before health problems arise, so as to have the optimal benefits of cessation.
Penyakit ginjal kronik (PGK) adalah proses patologis yang mengakibatkan penurunan progresif fungsi ginjal yang ditandai dengan penurunan laju filtrasi glomerulus. Penyakit ginjal kronik dapat mengakibatkan terjadinya anemia dan osteodistrofi renal. Anemia merupakan komplikasi penyakit ginjal kronik yang paling sering terjadi. Penelitian ini dilakukan untuk mengetahui hubungan laju filtrasi glomerulus dengan derajat anemia penderita PGK di RSUP Dr. Mohammad Hoesin Palembang. Penelitian ini merupakan penelitian analitik observasional dengan pendekatan cross sectional. Sampel penelitian ini adalah pasien yang didiagnosis penyakit ginjal kronik di RSUP Dr. Mohammad Hoesin Palembang dan tercatat di rekam medik tahun 2017 yang memenuhi kriteria inklusi dan eksklusi. Dari 214 pasien, didapatkan 55,1% penderita PGK adalah laki-laki dan 35% berumur 50-59 tahun. Berdasarkan derajat PGK didapatkan 79,4% penderita PGK memiliki derajat 5 dan berdasarkan derajat anemia didapatkan 94,9% penderita PGK mengalami anemia derajat sedang dan berat. Nilai cutoff LFG dan kadar Hb pada seluruh sampel didapatkan nilai < 8,56 mL/min/1,73m2, pada laki-laki < 8,1 mL/min/1,73m2, dan pada perempuan < 9,43mL/min/1,73m2. Hasil analisis menggunakan uji Chi-square menunjukkan bahwa LFG memiliki hubungan yang signifikan dengan derajat anemia (p=0,000). Terdapat hubungan yang signifikan antara laju filtrasi glomerulus dan derajat anemia pada penderita penyakit ginjal kronik di RSUP Dr. Mohammad Hoesin Palembang maka laju filtrasi glomerulus merupakan faktor risiko dari derajat anemia.
Pemberian ASI eksklusif pada bayi telah dianjurkan oleh semua pihak. ASI tidak hanya dapat memenuhi kebutuhan energi bayi, tetapi juga memberikan makronutrien dan mikronutrien yang penting untuk tumbuh kembang bayi. Walaupun demikian, cakupan pemberian ASI eksklusif belum dapat dikatakan optimal. Hal tersebut dipengaruhi oleh kurangnya pengetahuan ibu mengenai kandungan nutrisi ASI dan faktor ibu yang bekerja. Pengabdian masyarakat ini bertujuan untuk memberikan edukasi kepada ibu menyusui mengenai kandungan ASI dan pemberian ASI perah (ASIP). Kegiatan dilakukan secara online melalui Zoom. Kegiatan berupa seminar atau penyuluhan dengan menghadirkan 3 topik dan 3 narasumber. Evaluasi keberhasilan kegiatan dilakukan dengan menilai suasana diskusi dan memberikan pertanyaan tertutup melalui pra dan pascates. Sebanyak 29 ibu menyusui mengikuti kegiatan ini dengan rerata usia 29 tahun dan sebagian besar bekerja (80%). Para peserta antusias memberikan pertanyaan kepada para narasumber. Hasil evaluasi pra dan pascates menunjukkan ada peningkatan pengetahuan ibu menyusui sebesar 31% (p=0,000). Kegiatan pengabdian masyarakat berupa edukasi kandungan ASI dan pemberian ASIP berhasil dilakukan dengan baik. Edukasi mampu meningkatkan pengetahuan ibu menyusui. Edukasi atau penyuluhan dapat dilakukan untuk meningkatkan pengetahuan atau pemahaman masyarakat.Abstrak ditulis dalam bahasa Indonesia dan Inggris. Kata kunci: ASI, ASIP, edukasi, nutrisi, pengetahuan ABSTRACT Exclusive breastfeeding for babies has been recommended. It fulfills the baby's energy needs and provides nutrients that are necessary for baby's growth and development. However, the coverage of exclusive breastfeeding has not yet been sufficient, that is affected by the mother’s lack of knowledge about breast milk and the mother’s occupation. This community service aims to provide education to breastfeeding mothers about the content of breast milk and expressed breast milk to the breastfeeding mothers. The activities were performed by presenting 3 experts using online Zoom. Evaluation was done by assessing the atmosphere of the discussion and establishing closed questions through pre and post-test. A total of 29 breastfeeding mothers have participated in this activity with an average age of 29 years and most of them have job (80%). The participants were actively asking questions to the speakers. The results of the pre- and post-test evaluation showed that there was an increase in knowledge of breastfeeding mothers by 31% (p=0.000). It concludes that community service in the form of education activities on the content of breast milk and breastfeeding has been successful. Education or outreach activities has been proven to increase public’s knowledge and understanding of certain topic. Keywords: breast milk, education, expressed breast milk, knowledge, nutrition
Pada pertengahan tahun 2021 kasus Covid19 di Indonesia melonjak lagi termasuk di Kota Palembang. Lonjakan kasus tersebut tidak hanya memberikan dampak bagi masyarakat luas tetapi juga bagi lingkungan kampus Universitas Sriwijaya. Oleh karena itu, perlu dilakukan upaya meningkatkan imunitas tubuh menggunakan herbal tradisional Indonesia. Salah satu tanaman yang memiliki manfaat sebagai imunostimulator adalah tanaman sungkai. Kegiatan pengabdian kepada masyarakat ini berupa pembuatan teh dari daun sungkai. Proses pembuatan teh dilakukan di Laboratorium Kimia Dasar Kedokteran Fakultas Kedokteran Universitas Sriwijaya. Sekitar 27 kg daun sungkai segar dicuci dan dipotong kecil lalu dikeringkan. Daun sungkai kering digiling menjadi serbuk kasar (simplisia). Jumlah simplisia daun sungkai yang didapatkan sekitar 5,1 kg. Takaran sekali minum daun sungkai adalah sekitar 25 g untuk daun segar dan 3 g untuk simplisia. Simplisia daun sungkai dimasukkan ke dalam kantong teh dengan berat bersih 3 g per kantong. Satu kantong teh dapat diseduh dengan 240 mL air panas dan diminum 1-2 kali sehari selama 5 hari. Pada pengabdian ini dihasilkan 1700 kantong teh yang dikemas dalam 340 kemasan (5 kantong teh/kemasan). Produksi teh daun sungkai telah dilakukan dengan baik lalu dibagikan ke civitas akedemika melalui Dekan Fakultas Kedokteran dan Rektor Universitas Sriwijaya. Kata kunci: Covid19, Daun sungkai, Imunostimulator, Simplisia, Teh ABSTRACT In mid-2021, Covid-19 cases in Indonesia began to increase, including in Palembang. This condition not only has an impact on society but also for Sriwijaya University. To reduce the impact of Covid19, it is possible to increase the body's immunity with traditional Indonesian herbs, Sungkai. Sungkai has benefit as an immunostimulator. This community service is in the form of tea production from sungkai leaves. The process of making tea is carried out at Laboratorium Kimia Dasar Kedokteran, Faculty of Medicine, Universita Sriwijaya. About 27 kg of fresh sungkai leaves are washed, cut, and then dried to obtain about 5.1 kg of simplicia. The daily dose of sungkai leaves is about 25 g for fresh leaves and 3 g for simplicia. About 3 g simplicia was put into tea bags. One tea bag can be brewed with 240 mL of hot water and drunk 1-2 times a day for 5 days. A total of 1700 tea bags were produced and packaged in 340 packages (5 tea bags/package). Sungkai leaf tea production has been carried out well and then distributed to the academic community through the Dean of the Faculty of Medicine and the Chancellor of Universitas Sriwijaya. Keywords: Covid19, Sungkai leaf, Immunostimulator, Simplicia, Tea
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