Environmental factors, including pollutants and lifestyle, constitute a significant role in severe, chronic pathologies with an essential societal, economic burden. The measurement of all environmental exposures and assessing their correlation with effects on individual health is defined as the exposome, which interacts with our unique characteristics such as genetics, physiology, and epigenetics. Epigenetics investigates modifications in the expression of genes that do not depend on the underlying DNA sequence. Some studies have confirmed that environmental factors may promote disease in individuals or subsequent progeny through epigenetic alterations. Variations in the epigenetic machinery cause a spectrum of different disorders since these mechanisms are more sensitive to the environment than the genome, due to the inherent reversible nature of the epigenetic landscape. Several epigenetic mechanisms, including modifications in DNA (e.g., methylation), histones, and noncoding RNAs can change genome expression under the exogenous influence. Notably, the role of long noncoding RNAs in epigenetic processes has not been well explored in the context of exposome-induced tumorigenesis. In the present review, our scope is to provide relevant evidence indicating that epigenetic alterations mediate those detrimental effects caused by exposure to environmental toxicants, focusing mainly on a multi-step regulation by diverse noncoding RNAs subtypes.

El lenguaje según Noam Chomsky, es una capacidad innata que puede emplearse para comunicar la ciencia. Analizar el término obesidad como concepto científico, permitirá su correcto abordaje epistemológico para contribuir con la investigación científica multidisciplinaria que busca reducir esta pandemia. La obesidad es una acumulación excesiva de grasa corporal, por encima de las necesidades fisiológicas y capacidad de adaptación, que puede conducir a efectos adversos para la salud, como una discapacidad. Se considera un estado en el que el tejido adiposo representa más del 20% del peso corporal total en hombres y el 25% en mujeres. Un IMC de 30 kg/m2 o más se cataloga como obesidad. Desde una perspectiva genética, la obesidad es clasificada en tres subdivisiones de acuerdo con el trastorno y número de genes involucrados: monogénica, sindrómica y poligénica. Para las ciencias sociales, involucra un problema sociocultural injertado en una predisposición a nivel individual. Desde la perspectiva evolutiva, el cuerpo humano no está desarrollado para la exposición constante a un ambiente rico en calorías y sedentario. Comprender las perspectivas teóricas actuales que conceptualizan a la obesidad, estipulada como patología en sí misma, como factor de riesgo para las demás enfermedades no transmisibles y como etiología indirecta de discapacidad, permitirá que la investigación científica pueda desarrollarse con panoramas más amplios, a través de su diseño con variables, categorías y teorías mixtas, que permitan formular hipótesis y explicaciones con un enfoque multidisciplinario, en concordancia con la etiología multifactorial de la obesidad.  Abstract. Language according to Noam Chomsky, is an innate ability that can be used to communicate science. Analyzing the term obesity as a scientific concept will allow its correct epistemological approach to contribute to multidisciplinary scientific research that seeks to reduce this pandemic. Obesity is an excessive accumulation of body fat, in excess of physiological needs and adaptability, which can lead to adverse health effects, such as disability. It is considered a state in which adipose tissue represents more than 20% of total body weight in men and 25% in women. A BMI of 30 kg / m2 or more is classified as obesity. From a genetic perspective, obesity is classified into three subdivisions according to the disorder and number of genes involved: monogenic, syndromic and polygenic. For the social sciences, it involves a sociocultural problem grafted onto a predisposition at the individual level. From an evolutionary perspective, the human body is not developed for constant exposure to a calorie-rich and sedentary environment. Understanding the current theoretical perspectives that conceptualize obesity, stipulated as a pathology in itself, as a risk factor for other non-communicable diseases and as an indirect etiology of disability, will allow scientific research to be developed with broader perspectives, through its design with mixed variables, categories and theories, which allow the formulation of hypotheses and explanations with a multidisciplinary approach, in accordance with the multifactorial etiology of obesity.

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