Lactobacillus spp. are one of the first microorganisms involved in the development of dental caries in the first years of life of the child. The purpose of this study was to investigate the antibacterial effect of alcoholic extract of hypericin against strains of Lactobacillus spp. and determine its related MIC (minimum inhibitory concentration); and cytotoxic effect against gingival fibroblasts. Antimicrobial activity and MIC were evaluated using micro broth dilution method based on CLSI (clinical and laboratory standards institute) protocols. Determination of cytotoxicity was done by using MTT assay protocol on gingival fibroblast cells at 24, 48 and 72 hours after adding different concentrations of alcoholic extract of hypericin. Hypericin extract had an antimicrobial effect on lactobacillus spp., and its MIC was determined to be 0.625µg/ml . The IC50 value after 24, 48 and 72 hours was obtained as 0.89μg/ml, 0.7μg/ml and 0.604μg/ml, respectively. Hypericin extract MIC for L.acidophilus spp. was 0.625µg/ml and given that, MIC was less than IC50. This concentration does not have toxic effects on gingival fibroblast cells. The results of this study indicate that hypericin extract was able to eliminate acid producing strains in the mouth and can be evaluated as a suitable and safe substitute for mouthwashes and oral disinfectants.

Background: Traumatic dental injuries can be considered as an important social problem because they can affect daily lives of children, and their management is a major challenge in dentistry. Therefore, the aim of this study was to determine the primary school healthcare teachers' knowledge regarding the management of avulsed teeth in Tabriz, Iran. Methods: In this descriptive cross-sectional study, 160 healthcare teachers were selected from Tabriz schools. A questionnaire was used to collect data on demographic characteristics and knowledge. Data were analyzed through descriptive statistics and independent t-test, using SPSS version 16.0. Statistical significance was set at P < 0.05. Results: Among 160 healthcare teachers, 2.5% were male and 97.5% were female. The mean age of the participants was 39.2±4.6 years. All the healthcare teachers had university education and 89.4% (143 subjects) of them had bachelor's degrees. Of all the subjects, 96 (60%), 58 (36.2%) and 6 (3.8%) teachers had poor, moderate and good knowledge, respectively. Conclusions: The knowledge of school healthcare teachers in Tabriz about management of avulsed teeth is inadequate. Therefore, it is suggested that appropriate training programs be provided in this area, and it is recommended that the management of dental injuries be reviewed in educational programs and other health-related topics.

Abstract Background: Pyogenic granuloma is a common tumor like growth of the oral cavity that has been considered to be non-neoplastic in nature and a reactive lesion. Objective: This study aimed to investigate the prevalence of pyogenic granuloma lesion in pathology Department of Tabriz Dental School between years 2006-2016. Methods: In this cross-sectional study, 1081 clinical records were analyzed. Findings: Eighty-two patients, 36 (43.9%) male and 46 (56.1%) female with pyogenic granuloma were identified. Most of patients (26.8%) were in the second decade of life. The frequency of this lesion was highest in the gingiva area (57.8%) and lowest in the lip and buccal mucosa (3.7%). Conclusion: Results showed that between years of study, 82 cases of pyogenic granuloma has been recorded. Prevalence of this lesions was higher in women and in second decade of life. Most of the lesions were in the gingival area. : 93-98. ‫ﻗﺰوﯾﻦ‬ ‫ﭘﺰﺷﮑﯽ‬ ‫ﻋﻠﻮم‬ ‫داﻧﺸﮕﺎه‬ ‫ﻋﻠﻤﯽ‬ ‫ﻣﺠﻠﻪ‬ ‫ﺷﻤﺎره‬ ‫دوم،‬ ‫و‬ ‫ﺑﯿﺴﺖ‬ ‫ﺳﺎل‬ ، 3 ‫ﭘﯽ‬ ‫در‬ ‫)ﭘﯽ‬ 98 ‫ﺷﻬﺮﯾﻮر‬ ‫و‬ ‫ﻣﺮداد‬ ،( 1397 / ‫ﮐﻮﺗﺎه‬ ‫ﮔﺰارش‬ ‫ﮔﺮاﻧﻮﻟﻮﻣﺎ‬ ‫ﭘﯿﻮژﻧﯿﮏ‬ ‫ﺿﺎﯾﻌﻪ‬ ‫ﻓﺮاواﻧﯽ‬ ‫در‬ ‫آﺳﯿﺐ‬ ‫ﺑﺨﺶ‬ ‫دﻧﺪان‬ ‫داﻧﺸﮑﺪه‬ ‫ﺷﻨﺎﺳﯽ‬ ‫ﺑﯿﻦ‬ ‫ﺗﺒﺮﯾﺰ‬ ‫ﭘﺰﺷﮑﯽ‬ ‫ﺳﺎل‬ ‫ﻫﺎ‬ ‫ي‬ 1385 ‫ﺗﺎ‬ 1395 ‫دﮐﺘﺮ‬ ‫ﭘﺎﮐﺪل‬ ‫ﻓﺮزاﻧﻪ‬