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Demand Response Management (DRM) is considered one of the crucial aspects of the smart grid as it helps to lessen the production cost of electricity and utility bills. DRM becomes a fascinating research area when numerous utility companies are involved and their announced prices reflect consumer’s behavior. This paper discusses a Stackelberg game plan between consumers and utility companies for efficient energy management. For this purpose, analytical consequences (unique solution) for the Stackelberg equilibrium are derived. Besides this, this paper presents a distributed algorithm which converges for consumers and utilities. Moreover, different power consumption activities on the basis of time series are becoming a basic need for load prediction in smart grid. Load forecasting is taken as the significant concerns in the power systems and energy management with growing technology. The better precision of load forecasting minimizes the operational costs and enhances the scheduling of the power system. The literature has discussed different techniques for demand load forecasting like neural networks, fuzzy methods, Naïve Bayes, and regression based techniques. This paper presents a novel knowledge based system for short-term load forecasting. The algorithms of Affinity Propagation and Binary Firefly Algorithm are integrated in knowledge based system. Besides, the proposed system has minimum operational time as compared to other techniques used in the paper. Moreover, the precision of the proposed model is improved by a different priority index to select similar days. The similarity in climate and date proximity are considered all together in this index. Furthermore, the whole system is distributed in sub-systems (regions) to measure the consequences of temperature. Additionally, the predicted load of the entire system is evaluated by the combination of all predicted outcomes from all regions. The paper employs the proposed knowledge based system on real time data. The proposed scheme is compared with Deep Belief Network and Fuzzy Local Linear Model Tree in terms of accuracy and operational cost. In addition, the presented system outperforms other techniques used in the paper and also decreases the Mean Absolute Percentage Error (MAPE) on a yearly basis. Furthermore, the novel knowledge based system gives more efficient outcomes for demand load forecasting.

Aim: This case report suggests proper management of patients co-infected with both HCV and TB. Patients & methods: A 77-year-old female patient visited a primary care physician for a routine follow-up because she had past history of HCV in 2011, but she was successfully treated with interferon-therapy. She experienced HCV relapse in 2016 but did not respond to sofosbuvir and ribavirin and it was later on confirmed that she had TB which made the treatment of HCV more challenging. Results: This is the first evidence that highlights sofosbuvir, daclatasvir and ribavirin as an optimal treatment regimen for patients co-infected with TB. Furthermore, it is necessary to treat TB before initiating HCV treatment because of risk of hepatotoxicity. Conclusion: Co-infection of TB in HCV patients alters treatment response toward nucleotide analog inhibitor, sofosbuvir, an approved anti-HCV drug with high rate of sustained virological response.

Aim: This study aimed to determine the efficacy of direct-acting antiviral drugs in different ethnicities and elderly population of Pakistan. Methods: We used GeneXpert® technology to quantify HCV RNA and evaluated treatment response in different cohorts that included HCV patients classified on the basis of their age-group and ethnicity. Results: The findings of our study suggest that 76% of nonresponder patients were older than 55 years of age which shows that age is the predictor of treatment outcome of direct-acting antiviral drugs. In addition to this, no differences were observed in overall efficacy by ethnicity. Conclusion: Treatment-regimen sofosbuvir+ribavirin has a limited effect on older patients; therefore, practitioners and healthcare professionals need to reconsider treatment options for elderly populations.