β-thalassemia is an inherited blood disorder in which the body cannot produce hemoglobin normally. Since patients with this condition receive blood transfusions regularly, iron builds up primarily in organs such as the heart, liver and endocrine glands. Accumulation of iron in the organs necessitates chelation therapy. These patients must visit the hospital frequently to assess and follow up on their health condition. Physician intervention is required after each regular assessment to adjust the treatment. Lifelong healthcare support using a web-based expert system with a quick response code is designed for β-thalassemia management in order to deliver benefits to patients, physicians, and other healthcare providers. The aim of this study is to implement a web-based expert system for β-thalassemia management in order to provide treatment recommendations and support the lifelong healthcare of patients. The system provides patient-related details, such as medical history, medicines, and appointments, in real-time. It has been also tested in real-life cases and shown to enhance β-thalassemia management.

The treatment of patients with sickle cell disease frequently requires transfusion of red blood cells. Complications due to alloimmunization of red blood cells antigen remain a major risk as a post transfusion effect. The objective of this study is to determine the frequency of red cell alloimmunization in Jeddah, Saudi Arabia. A retrospective cross-section study of sickle cell disease patients at King Abdulaziz University Hospital between 2012 and 2013 was performed. Demographic characteristics and transfusion history was recorded. Blood samples were analyzed for alloimmunization using immunohematological technique. A total of 234 sickle cell patients were analyzed, of which 30 (12.8%) showed alloantibodies. A total of 43 alloantibodies were found out of which 28 belonged to Rh group, eight belonged to Kell while three belonged to MNS group. Demographic and transfusion characteristics were analyzed between alloimmunized and nonalloimmunized sickle cell disease patients. The rate of alloimmunization in Jeddah, Saudi Arabia was 12.8%. There was significant difference observed between alloantibodies detection between transfused patients compared to non-transfused patients. The consequences of red blood cell alloimmunization are highly significant and therefore immune hematological testing is highly recommended.

Background and objective:The objectives of the study research were to determine the relationship between clinical and chest X-ray findings of pediatric patients. Methods: A Prospective clinical study carried out at Raparin hospital in Erbil city, Iraq. A sample of 356 children admitted between Decembers 2004 and June 2005 from emergency ward and inwards in Raparin hospital were collected with age range from 2 months to 10 years with mean age of 19 months. All children had chest radiography on the bases of clinical decision by pediatricians. Descriptive and statistical procedures were used to analyze the data. Results: All children had signs and symptoms of respiratory infections for instance, fever (87.4%), shortness of breath (99.5 %),cough (98%), tachypnea (73.5%), wheezes (93.3% ), chest retraction (80%), crepitations (82%) and, 42.4% of chest X-rays showed focal infiltrations. Three clinical parameters related to pneumonia diagnosed by chest X-ray these were, chest retraction with sensitivity of 80%, and specificity of 88.29%), tachypnea with sensitivity of 73.5% and specificity of 56.59% fever with sensitivity of 87.42% and specificity of 60.98%. Conclusion: Tachypnea, chest retraction and fever were found to be highly suggestive of pneumonia, chest x-rays was positive in about 425 of patients with pneumonia.

Background. β-thalassemia is an inherited blood disorder that affects the production of hemoglobin molecules owing to the reduction or absence of beta chains. Transfusion therapy has had a key role in extending the lifespan of β-thalassemia patients. This life-saving therapy is linked to numerous assessments and complications that now comprise most thalassemia management considerations. Consequently, many patients do not receive adequate information about the required assessments, as indicated by evidence-based medical guidelines. Patients with β-thalassemia may benefit from chatbots that follow up on their condition and that provide the required assessment information. Self-management will hopefully have a positive impact on health outcomes. Objectives. This study aims to develop a chatbot that can assist in the management of β-thalassemia by providing the assessment information required to monitor patients’ statuses. Methods. The chatbot operated as a messaging system. A question/answer system was created based on knowledge pertaining to β-thalassemia assembled from experts, medical guidelines, and articles. Recommendations regarding the patient’s follow-up assessment are made based on the answers. Results. A prototype was implemented to demonstrate how the chatbots could dynamically and flexibly provide the assessment information required to follow up on and monitor patients. A small sample of adults with β-thalassemia used the chatbot to examine the system’s usability and perceived utility. A system usability scale and utility scale were implemented to complete a post-test survey. The chatbots were considered by 34 patients, of whom the majority (72%) found them easy to use, while more than 90% of patients considered their use beneficial. Most of the participants agreed that the chatbots could improve their knowledge about their β-thalassemia assessments. Conclusion. Our findings suggest that chatbots can be beneficial to the development of recommended tests and management related to the assessment of β-thalassemia.

The aim of the study is to assess the alloimmunization rate to red blood cell in thalassemia patients at King Abdulaziz University Hospital. Thalassemia is the most common genetic disorder worldwide that represents a major public health problem and requires long life blood transfusion to the patients as the main treatment. Alloimmunization to the transfused red blood cell can cause hemolytic transfusion reactions and significantly complicate transfusion therapy. Screening and identification of alloantibodies and transfusion of extended phenotyped blood can minimize these risks. A retrospective study was conducted on 134 thalassemia patients at King Abdulaziz University Hospital in Jeddah. Patients’ samples were subjected to red cell typing, antibody screening and identifi cation of red blood cell antibodies. Alloimmunization in thalassemia patients was 20.15%; antibodies were mainly to the Rh and Kell blood group systems, the highest rate was for anti-E (32.4%) followed by anti-K (21.6%). Alloimmunization rate was the highest in the age group from > 10 – 20 years (40.7%). Red cell alloimmunization is a frequent event among thalassemia patient. A national protocol for screening and identifying of the red cell alloantibodies and transfusion of phenotype blood is required for proper management of these patients.