Objective:To assess the effectiveness of integrative weaning index (IWI) as a predictor of weaning success.Materials and Methods:This is a prospective randomized controlled observer-blinded study and carried out on 120 patients of both sexes; patients who received mechanical ventilation for more than 24 h and met defined criteria for a weaning trial, underwent a 2-h spontaneous breathing trial with either IWI plus routine criteria of weaning (Group I n = 60) or routine criteria of weaning alone (control group) (Group C n = 60), in Group C the IWI was measured retrospective as it is not used in weaning decision. Those tolerated the trial would be immediately extubated. The primary outcome measure was the ability to maintain spontaneous, unassisted breathing for more than 48 h after extubation. Secondary outcome measures were the duration of mechanical ventilation, length of Intensive Care Unit (ICU) stay, and length of hospital stay.Results:The mean duration (hours) of mechanical ventilation and length of ICU stay (days) were significantly shorter in the Group I where the IWI was used (83.6 ± 34.3 vs. 97.49 ± 47.2 h, P = 0.002 and 5.5 ± 1.6 vs. 7.12 ± 2.3 days, P = 0.03, respectively). Weaning success rate was significantly higher in the Group I (53 vs. 34, P = 0.0001) while weaning failure rate was significantly lower in the Group I C (7 vs. 26, P = 0.0001).Conclusion:IWI is a strong predictor of both successful and failed weaning.

IntroductionIn obstructive sleep apnea ( OSA), there is increased oxidative stress. Aim of this workThis study aimed to examine the effect of continuous positive airway pressure (CPAP) on oxidative stress occurring in OSA. Participants and methodsThe present study was carried out on 40 individuals classifi ed into four groups: group I included 10 control participants, group II included 10 obese individuals without OSA, group III included 10 patients with mild to moderate OSA, and group IV included 10 patients with severe OSA. Sleep study was carried out, and Thiobarbituric acid-reactive substance and superoxide dismutase enzyme were measured. ResultsThiobarbituric acid-reactive substance was signifi cantly increased, but superoxide dismutase was signifi cantly decreased in group IV, and CPAP led to an improvement in this condition. ConclusionOSA leads to increased oxidative stress that improved with the use of CPAP.

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