Medicinal plants have been used since ancient times for their various therapeutic activities and are safer compared to modern medicines, especially when properly identifying and preparing them and choosing an adequate dose administration. The phytochemical compounds present in plants are progressively yielding evidence in modern drug delivery systems by treating various diseases like cancers, coronary heart disease, diabetes, high blood pressure, inflammation, microbial, viral and parasitic infections, psychotic diseases, spasmodic conditions, ulcers, etc. The phytochemical requires a rational approach to deliver the compounds to enhance the efficacy and to improve patients’ compatibility. Nanotechnology is emerging as one of the most promising strategies in disease control. Nano-formulations could target certain parts of the body and control drug release. Different studies report that phytochemical-loaded nano-formulations have been tested successfully both in vitro and in vivo for healing of skin wounds. The use of nano systems as drug carriers may reduce the toxicity and enhance the bioavailability of the incorporated drug. In this review, we focus on various nano-phytomedicines that have been used in treating skin burn wounds, and how both nanotechnology and phytochemicals are effective for treating skin burns.

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Skin illnesses affect 30%-70% of the world's population, symptoms might range from acute to chronic, benign to fatal. According to the Global Burden of Disease report in 2010, skin problems are now the fourth greatest source of non-fatal disease burden. Dermatitis inflammation, infection (caused by pathogens like viruses, fungi, and bacteria), auto-immune ailments such as psoriasis/atopic dermatitis,

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Psoriasis is an autoimmune skin condition that is also inflammatory and proliferative. Psoriasis is caused by activation of T-cells and is distinguished by prominent, drab-red, or peach-pink tight patches with silvery scales on the skin. In recent years, there have been some significant advances in the study of the etiology of inflammatory skin diseases such as psoriasis. The nanotechnology-based novel formulation provides a great occasion for enhancing the efficacy and safety of pharmacotherapeutic agents for psoriasis. The benefits of nanotechnological techniques to offer an effective drug concentration in the disease site and nanocarrier as innovative possibilities for drug delivery systems in psoriasis and other inflammatory chronic skin disorder are highlighted in this area. We have explored the mechanisms underlying the pathogenic aspects of psoriasis in this review, as well as phytoconstituents, naturally occurring substances found in plants with anti-psoriatic properties. Anti-psoriatic action is attributed to phytochemicals that target cytokine signaling pathways. We also discussed the benefits of loading phytoconstituents as drugs in nanocarriers such as liposomes, niosomes, invasomes, phytosomes, transferosomes, and pro-niosomes for improved topical therapy and delivery of phytoconstituents with a better therapeutic profile and lower toxicity.