Phytochemical-Based Nano-Pharmacotherapeutics for Management of Burn Wound Healing

Qadir, Abdul; Jahan, Samreen; Aqil, Mohd.; Warsi, Musarrat Husain; Alhakamy, Nabil A.; Alfaleh, Mohamed A.; Khan, Nausheen; Ali, Athar

doi:10.3390/gels7040209

Cited by 26 publications

(9 citation statements)

References 158 publications

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“…Preventing infection on wounds and treatment remains challenging due to the development of resistance and the tendency to form biofilm on wounds that protects pathogens from host defense mechanisms [ 35 ]. To overcome antibiotic resistance development in bacterial pathogens, natural components and novel phytochemicals with high potency to heal wounds and antimicrobial properties are being explored [ 36 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis

et al. 2022

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The present study investigated the wound healing activity of Moringa oleifera leaf extract on an infected excision wound model in rats. Infection was induced using methicillin-resistant Staphylococcus aureus (MRSA) or Pseudomonas aeruginosa. An investigation was also done to study the effect of Moringa extract on the vascular endothelial growth factor (VEGF) and transforming growth factor-beta 1 (TGF-β1) gene expression in vitro using human keratinocytes (HaCaT). The methanol extract of M. oleifera leaves was analyzed for the presence of phytochemicals by LCMS. The antimicrobial activity of the extract was also determined. Wound contraction, days for epithelization, antioxidant enzyme activities, epidermal height, angiogenesis, and collagen deposition were studied. M. oleifera showed an antimicrobial effect and significantly improved wound contraction, reduced epithelization period, increased antioxidant enzymes activity, and reduced capillary density. Effect of the extract was less in wounds infected with P. aeruginosa when compared to MRSA. The VEGF and TGF-β1 gene expression was increased by M. oleifera.

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Section: Discussionmentioning

confidence: 99%

Effect of Moringa oleifera Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis

et al. 2022

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“…The use of plant extracts in skin disorders has increased over the last two centuries due to the availability of active chemicals in these extracts. Herbal medicines are frequently used due to their effectiveness and low risk of side effects 151 . The use of herbal components for skin problems and other ailments is accepted by 80% of the public.…”

Section: Future Perspective and Conclusionmentioning

confidence: 99%

Drug delivery of natural products through nano‐carriers for effective vitiligo therapy: A compendia review

Qadir

Ullah

Jahan

et al. 2022

J of Cosmetic Dermatology

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Skin illnesses affect 30%-70% of the world's population, symptoms might range from acute to chronic, benign to fatal. According to the Global Burden of Disease report in 2010, skin problems are now the fourth greatest source of non-fatal disease burden. Dermatitis inflammation, infection (caused by pathogens like viruses, fungi, and bacteria), auto-immune ailments such as psoriasis/atopic dermatitis,

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“…Moreover, the extract from Acalypha indica L. (Euphorbiaceae), which is rich in alkaloids, flavonoids, and saponins, can be used in nano-formulations. This herb possesses anti-inflammatory and antioxidant properties, thus can be considered also in anticancer studies ( Qadir et al., 2021 ).…”

Section: Latex-bearing Plants and Nanotechnologymentioning

confidence: 99%

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

Mazur

Bałdysz²,

Warowicka³

et al. 2022

Front. Plant Sci.

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Latex-bearing plants have been in the research spotlight for the past couple of decades. Since ancient times their extracts have been used in folk medicine to treat various illnesses. Currently they serve as promising candidates for cancer treatment. Up to date there have been several in vitro and in vivo studies related to the topic of cytotoxicity and anticancer activity of extracts from latex-bearing plants towards various cell types. The number of clinical studies still remains scarce, however, over the years the number is systematically increasing. To the best of our knowledge, the scientific community is still lacking in a recent review summarizing the research on the topic of cytotoxicity and anticancer activity of latex-bearing plant extracts. Therefore, the aim of this paper is to review the current knowledge on in vitro and in vivo studies, which focus on the cytotoxicity and anticancer activities of latex-bearing plants. The vast majority of the studies are in vitro, however, the interest in this topic has resulted in the substantial growth of the number of in vivo studies, leading to a promising number of plant species whose latex can potentially be tested in clinical trials. The paper is divided into sections, each of them focuses on specific latex-bearing plant family representatives and their potential anticancer activity, which in some instances is comparable to that induced by commonly used therapeutics currently available on the market. The cytotoxic effect of the plant’s crude latex, its fractions or isolated compounds, is analyzed, along with a study of cell apoptosis, chromatin condensation, DNA damage, changes in gene regulation and morphology changes, which can be observed in cell post plant extract addition. The in vivo studies go beyond the molecular level by showing significant reduction of the tumor growth and volume in animal models. Additionally, we present data regarding plant-mediated biosynthesis of nanoparticles, which is regarded as a new branch in plant latex research. It is solely based on the green-synthesis approach, which presents an interesting alternative to chemical-based nanoparticle synthesis. We have analyzed the cytotoxic effect of these particles on cells. Data regarding the cytotoxicity of such particles raises their potential to be involved in the design of novel cancer therapies, which further underlines the significance of latex-bearing plants in biotechnology. Throughout the course of this review, we concluded that plant latex is a rich source of many compounds, which can be further investigated and applied in the design of anticancer pharmaceuticals. The molecules, to which this cytotoxic effect can be attributed, include alkaloids, flavonoids, tannins, terpenoids, proteases, nucleases and many novel compounds, which still remain to be characterized. They have been studied extensively in both in vitro and in vivo studies, which provide an excellent starting point for their rapid transfer to clinical studies in the near future. The comprehensive study of molecules from latex-bearing plants can result in finding a promising alternative to several pharmaceuticals on the market and help unravel the molecular mode of action of latex-based preparations.

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Phytochemical-Based Nano-Pharmacotherapeutics for Management of Burn Wound Healing

Cited by 26 publications

References 158 publications

Effect of Moringa oleifera Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis

Effect of Moringa oleifera Leaf Extract on Excision Wound Infections in Rats: Antioxidant, Antimicrobial, and Gene Expression Analysis

Drug delivery of natural products through nano‐carriers for effective vitiligo therapy: A compendia review

Tap the sap – investigation of latex-bearing plants in the search of potential anticancer biopharmaceuticals

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