Introduction. Pressure ulcers are skin lesions that occur as a result of an ischemia process, this type of lesion are considerated very important in the health context. Objective. To identify associated factors with the appearance of pressure ulcers in hospitalized patients over 16 years old, in a teaching hospital in Bogotá Colombia during 2013. Materials and methods. A case-control study was carried out, based on a secondary information source. Some variables and their relationship with the presentation of pressure ulcers in each case were analyzed. Results 228 patients were included, 114 cases, 114 controls, the bivariate analysis to identify the factors associated with the risk of presenting pressure ulcers: age equal to or greater than 45 years, pathologies of respiratory etiology, with levels of hemoglobin and albumin below the range expected for sex and age, multivariate analysis that patients older than 45 years, hemoglobin below the expected level by sex and age, have a high risk of presenting UPP for each day of hospital stay. Conclusions The early identification of factors associated with UPP constitutes a fundamental pillar in care.