The early introduction of solid foods to an infant's diet does not alter growth or body composition during the first year of life and results in a displacement of energy intake from formula. Infants consuming commercially prepared foods have a decreased caloric intake from protein and fat; however, despite this difference, there is no effect on growth or body composition.

The 1995 edition of Dietary Guidelines for Americans has recently been released. In anticipation of the heightened attention that these revised guidelines will undoubtedly receive, there is renewed discussion about the need for Dietary Guidelines for Infants. These guidelines would reinforce to parents and nutrition professionals that many diet strategies designed to promote adult health and nutrition are inappropriate for infants and children under the age of two. These guidelines, developed in 1994 by the Gerber Products Company, seek to distinguish the unique dietary needs of this vulnerable population.

Background. Iron deficiency continues to be a common problem among infants throughout the world. Iron-fortified formula is effective in preventing iron deficiency but the benefit of iron-fortified cereal is controversial. Methods. We compared iron-fortified rice cereal to unfortified rice cereal in infants who were exclusively breast-fed for more than 4 months and to iron-fortified formula in infants who were weaned to formula before 4 months of age. The design was double blind in respect to the presence or absence of fortification iron in the cereal or formula and included 515 infants who were followed on the protocol from 4 to 15 months of age. Rice cereal was fortified with 55 mg of electrolytic iron per 100 g of dry cereal and infant formula with 12 mg of ferrous sulfate per 100 g of dry powder, levels approximating those in use in the United States. Measures of iron status were obtained at 8, 12, and 15 months. Infants with hemoglobin levels of <105 g/L were excluded from the study and treated. Results. Consumption of cereal reached plateaus at means of about 30 g/d after 6 months of age in the formula-fed groups and 26 g/d after 8 months in the breast-fed groups; these amounts are higher than the 19-g/d mean intake by the 73% of infants who consume such cereal in the United States. Among infants weaned to formula before 4 months, the cumulative percentages of infants excluded for anemia by 15 months were 8%, 24%, and 4%, respectively, in the fortified cereal, unfortified cereal and formula, and fortified formula groups (P < .01 unfortified vs either fortified group; the difference between the two fortified groups was not significant). In infants breast-fed for more than 4 months, the corresponding values were 13% and 27%, respectively, in the fortified and unfortified cereal groups (P < .05). Mean hemoglobin level and other iron status measures were in accord with these findings. Conclusion. Iron-fortified infant rice cereal can contribute substantially to preventing iron deficiency anemia.

Hypertriglyceridemia and fatty livers have been observed in pups of Fe-deficient rats. Lowered tissue carnitine level is proposed as a mechanism responsible for altered lipid metabolism. Two hydroxylases involved in carnitine synthesis have been shown to require Fe in vitro. To determine if dietary Fe deficiency reduces tissue carnitine levels, two groups of 12 rats were fed 6 ppm Fe (-Fe) or 250 ppm Fe (+Fe) ad libitum from d 1 gestation to d 16 lactation. Feeding -Fe diets to dams resulted in 15% lower hemoglobin levels in pups on d 2 (P less than 0.02) and 50% lower levels on d 16 (P less than 0.001). Total carnitine level (nanomoles/milligram noncollagen protein) and triacylglycerol were assayed in pup tissues on d 2 and 16. While tissue carnitine and triacyglycerol was similar on d 2, d 16 liver carnitine was lower (P less than 0.001), triacylglycerol was eightfold higher in -Fe pups than in controls. Fe deficiency did not alter either carnitine concentration in milk on d 2 or 16 or the concentration of amino acid precursors of carnitine in milk on d 16. Decreased carnitine levels in the -Fe rat pup are contribute to triacylglycerol accumulation in liver.